Mitochondrial dysfunction and heart disease : Critical appraisal of an overlooked association
(2021) In International Journal of Molecular Sciences 22(2).- Abstract
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the... (More)
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.
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- author
- Bisaccia, Giandomenico ; Ricci, Fabrizio LU ; Gallina, Sabina ; Di Baldassarre, Angela and Ghinassi, Barbara
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac energetics, Cardiomyopathy, Heart failure, Mitochondria, Mitochondrial dynamics
- in
- International Journal of Molecular Sciences
- volume
- 22
- issue
- 2
- article number
- 614
- pages
- 19 pages
- publisher
- MDPI AG
- external identifiers
-
- pmid:33435429
- scopus:85099280785
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms22020614
- language
- English
- LU publication?
- yes
- id
- 9d90983f-a66c-43dd-b2bb-9ed11c619f1b
- date added to LUP
- 2021-01-25 10:13:05
- date last changed
- 2024-09-20 14:46:29
@article{9d90983f-a66c-43dd-b2bb-9ed11c619f1b,
abstract = {{<p>The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.</p>}},
author = {{Bisaccia, Giandomenico and Ricci, Fabrizio and Gallina, Sabina and Di Baldassarre, Angela and Ghinassi, Barbara}},
issn = {{1661-6596}},
keywords = {{Cardiac energetics; Cardiomyopathy; Heart failure; Mitochondria; Mitochondrial dynamics}},
language = {{eng}},
number = {{2}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Mitochondrial dysfunction and heart disease : Critical appraisal of an overlooked association}},
url = {{http://dx.doi.org/10.3390/ijms22020614}},
doi = {{10.3390/ijms22020614}},
volume = {{22}},
year = {{2021}},
}