Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome
Bläckberg, Anna LU ; Lundberg, Katrina LU ; Svedevall, Stina ; Nilson, Bo LU
and Rasmussen, Magnus
LU
(2023)
In Infectious Diseases
55(5).
p.333-339
- Abstract
- Purpose
Invasive infections with Streptococcus dysgalactiae predominantly occur in persons of older age with substantial morbidity and mortality. Time to positivity from blood cultures (TTP) has been shown to be a prognostic indicator in bloodstream infections caused by other beta-haemolytic streptococci. This study aimed to determine any possible association between TTP and outcome in invasive infections due to S. dysgalactiae.
Materials and methods
Episodes of S. dysgalactiae bacteraemia, that occurred during 2015–2018 in the Region of Skåne, Sweden, were identified through the laboratory database and retrospectively studied. Any association with TTP and the primary outcome, death within 30 days and the development of... (More) - Purpose
Invasive infections with Streptococcus dysgalactiae predominantly occur in persons of older age with substantial morbidity and mortality. Time to positivity from blood cultures (TTP) has been shown to be a prognostic indicator in bloodstream infections caused by other beta-haemolytic streptococci. This study aimed to determine any possible association between TTP and outcome in invasive infections due to S. dysgalactiae.
Materials and methods
Episodes of S. dysgalactiae bacteraemia, that occurred during 2015–2018 in the Region of Skåne, Sweden, were identified through the laboratory database and retrospectively studied. Any association with TTP and the primary outcome, death within 30 days and the development of sepsis or disease deterioration within 48 hours from blood culturing as secondary outcomes were investigated.
Results
Among the 287 episodes of S. dysgalactiae bacteraemia, 30-day mortality rate was 10% (n = 30). Median TTP was 9.3 h (interquartile range 8.0–10.3 h). Median TTP was statistically significantly shorter in patients who died within 30 days compared to surviving patients (7.7 vs 9.3 h, p = .001, Mann–Whitney U test). Short TTP(≤ 7.9 h) was still associated with 30-day mortality when adjusting for age, (OR 4.4, 95% CI 1.6–12.2, p = .004). Associations between secondary outcomes and levels of TTP were not observed.
Conclusion
TTP may be an important prognostic indicator for 30-day mortality in patients with bloodstream infections due to S. dysgalactiae. (Less) - Abstract (Swedish)
- PurposeInvasive infections with Streptococcus dysgalactiae predominantly occur in persons of older age with substantial morbidity and mortality. Time to positivity from blood cultures (TTP) has been shown to be a prognostic indicator in bloodstream infections caused by other beta-haemolytic streptococci. This study aimed to determine any possible association between TTP and outcome in invasive infections due to S. dysgalactiae.Materials and methodsEpisodes of S. dysgalactiae bacteraemia, that occurred during 2015-2018 in the Region of Skane, Sweden, were identified through the laboratory database and retrospectively studied. Any association with TTP and the primary outcome, death within 30 days and the development of sepsis or disease... (More)
- PurposeInvasive infections with Streptococcus dysgalactiae predominantly occur in persons of older age with substantial morbidity and mortality. Time to positivity from blood cultures (TTP) has been shown to be a prognostic indicator in bloodstream infections caused by other beta-haemolytic streptococci. This study aimed to determine any possible association between TTP and outcome in invasive infections due to S. dysgalactiae.Materials and methodsEpisodes of S. dysgalactiae bacteraemia, that occurred during 2015-2018 in the Region of Skane, Sweden, were identified through the laboratory database and retrospectively studied. Any association with TTP and the primary outcome, death within 30 days and the development of sepsis or disease deterioration within 48 hours from blood culturing as secondary outcomes were investigated.ResultsAmong the 287 episodes of S. dysgalactiae bacteraemia, 30-day mortality rate was 10% (n = 30). Median TTP was 9.3 h (interquartile range 8.0-10.3 h). Median TTP was statistically significantly shorter in patients who died within 30 days compared to surviving patients (7.7 vs 9.3 h, p = .001, Mann-Whitney U test). Short TTP( (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9db9d4e3-112f-45be-a0bb-47ef0e23fb77
- author
- Bläckberg, Anna
LU
; Lundberg, Katrina
LU
; Svedevall, Stina
; Nilson, Bo
LU
and Rasmussen, Magnus
LU
- organization
- publishing date
- 2023-05-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infectious Diseases
- volume
- 55
- issue
- 5
- pages
- 333 - 339
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:85149308865
- pmid:36847483
- ISSN
- 2374-4235
- DOI
- 10.1080/23744235.2023.2182910
- language
- English
- LU publication?
- yes
- id
- 9db9d4e3-112f-45be-a0bb-47ef0e23fb77
- date added to LUP
- 2023-08-08 16:39:42
- date last changed
- 2023-08-10 03:00:03
@article{9db9d4e3-112f-45be-a0bb-47ef0e23fb77,
abstract = {{Purpose<br/>Invasive infections with Streptococcus dysgalactiae predominantly occur in persons of older age with substantial morbidity and mortality. Time to positivity from blood cultures (TTP) has been shown to be a prognostic indicator in bloodstream infections caused by other beta-haemolytic streptococci. This study aimed to determine any possible association between TTP and outcome in invasive infections due to S. dysgalactiae.<br/><br/>Materials and methods<br/>Episodes of S. dysgalactiae bacteraemia, that occurred during 2015–2018 in the Region of Skåne, Sweden, were identified through the laboratory database and retrospectively studied. Any association with TTP and the primary outcome, death within 30 days and the development of sepsis or disease deterioration within 48 hours from blood culturing as secondary outcomes were investigated.<br/><br/>Results<br/>Among the 287 episodes of S. dysgalactiae bacteraemia, 30-day mortality rate was 10% (n = 30). Median TTP was 9.3 h (interquartile range 8.0–10.3 h). Median TTP was statistically significantly shorter in patients who died within 30 days compared to surviving patients (7.7 vs 9.3 h, p = .001, Mann–Whitney U test). Short TTP(≤ 7.9 h) was still associated with 30-day mortality when adjusting for age, (OR 4.4, 95% CI 1.6–12.2, p = .004). Associations between secondary outcomes and levels of TTP were not observed.<br/><br/>Conclusion<br/>TTP may be an important prognostic indicator for 30-day mortality in patients with bloodstream infections due to S. dysgalactiae.}},
author = {{Bläckberg, Anna and Lundberg, Katrina and Svedevall, Stina and Nilson, Bo and Rasmussen, Magnus}},
issn = {{2374-4235}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{333--339}},
publisher = {{Informa Healthcare}},
series = {{Infectious Diseases}},
title = {{Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome}},
url = {{http://dx.doi.org/10.1080/23744235.2023.2182910}},
doi = {{10.1080/23744235.2023.2182910}},
volume = {{55}},
year = {{2023}},
}