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Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting : A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study

Grins, Edgars LU orcid ; Ederoth, Per LU ; Bjursten, Henrik LU ; Dardashti, Alain LU ; Brondén, Björn LU ; Metzsch, Carsten LU ; Erdling, André LU ; Nozohoor, Shahab LU ; Mokhtari, Arash LU and Hansson, Magnus J. LU orcid , et al. (2022) In Journal of Cardiothoracic and Vascular Anesthesia 36(7). p.1985-1994
Abstract

Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At a tertiary care, university hospital. Participants: Patients eligible for elective coronary artery bypass grafting surgery; 67 patients were enrolled. Interventions: Patients were randomized to receive 2.5 mg/kg cyclosporine or placebo before surgery. Cytokine levels were measured after the induction of anesthesia and 4 hours after the end of... (More)

Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At a tertiary care, university hospital. Participants: Patients eligible for elective coronary artery bypass grafting surgery; 67 patients were enrolled. Interventions: Patients were randomized to receive 2.5 mg/kg cyclosporine or placebo before surgery. Cytokine levels were measured after the induction of anesthesia and 4 hours after the end of cardiopulmonary bypass. Measurements and Main Results: Tissue-aggressive (interleukin [IL]-1β, macrophage inflammatory protein [MIP]-1β, granulocyte colony-stimulating factor [G-CSF], IL-6, IL-8, IL-17, MCP-1), as well tissue-lenient (IL-4) cytokines, were significantly elevated in response to surgery. Changes in cytokine levels were not affected by cyclosporine pretreatment. Conclusions: Elective coronary artery bypass grafting surgery with cardiopulmonary bypass triggers cytokine activation. This activation was not impacted by preoperative cyclosporine treatment.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute kidney injury, cardiac surgery, cyclosporine, cystatin C, cytokines, IL-6
in
Journal of Cardiothoracic and Vascular Anesthesia
volume
36
issue
7
pages
1985 - 1994
publisher
Elsevier
external identifiers
  • scopus:85121921346
  • pmid:34969566
ISSN
1053-0770
DOI
10.1053/j.jvca.2021.11.026
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 Elsevier Inc.
id
9e992c36-b242-43fc-85fd-f92b22e9c708
date added to LUP
2022-01-16 16:26:44
date last changed
2024-10-06 11:53:23
@article{9e992c36-b242-43fc-85fd-f92b22e9c708,
  abstract     = {{<p>Objectives: The augmented inflammatory response to cardiac surgery is a recognized cause of postoperative acute kidney injury. The present study aimed to investigate the effects of preoperative cyclosporine treatment on cytokine production and delineate factors associated with postoperative kidney impairment. Design: A randomized, double-blind, placebo-controlled, single-center study. Setting: At a tertiary care, university hospital. Participants: Patients eligible for elective coronary artery bypass grafting surgery; 67 patients were enrolled. Interventions: Patients were randomized to receive 2.5 mg/kg cyclosporine or placebo before surgery. Cytokine levels were measured after the induction of anesthesia and 4 hours after the end of cardiopulmonary bypass. Measurements and Main Results: Tissue-aggressive (interleukin [IL]-1β, macrophage inflammatory protein [MIP]-1β, granulocyte colony-stimulating factor [G-CSF], IL-6, IL-8, IL-17, MCP-1), as well tissue-lenient (IL-4) cytokines, were significantly elevated in response to surgery. Changes in cytokine levels were not affected by cyclosporine pretreatment. Conclusions: Elective coronary artery bypass grafting surgery with cardiopulmonary bypass triggers cytokine activation. This activation was not impacted by preoperative cyclosporine treatment.</p>}},
  author       = {{Grins, Edgars and Ederoth, Per and Bjursten, Henrik and Dardashti, Alain and Brondén, Björn and Metzsch, Carsten and Erdling, André and Nozohoor, Shahab and Mokhtari, Arash and Hansson, Magnus J. and Elmér, Eskil and Algotsson, Lars and Shrestha, Nabin Manandhar and Jovinge, Stefan}},
  issn         = {{1053-0770}},
  keywords     = {{acute kidney injury; cardiac surgery; cyclosporine; cystatin C; cytokines, IL-6}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1985--1994}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Cardiothoracic and Vascular Anesthesia}},
  title        = {{Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting : A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study}},
  url          = {{http://dx.doi.org/10.1053/j.jvca.2021.11.026}},
  doi          = {{10.1053/j.jvca.2021.11.026}},
  volume       = {{36}},
  year         = {{2022}},
}