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Paradoxical role of hmgb1 in pancreatic cancer : Tumor suppressor or tumor promoter?

Cebrián, María José García; Bauden, Monika LU ; Andersson, Roland LU ; Holdenrieder, Stefan and Ansari, Daniel LU (2016) In Anticancer Research 36(9). p.4381-4390
Abstract

Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a protumor protein with cytokine, chemokine and growth factor functions. Although the exact mechanisms of HMGB1 in pancreatic cancer are still to be elucidated, the significance of this protein for processes, such as autophagy, immunogenic cell death, tumor growth, metastasis and... (More)

Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a protumor protein with cytokine, chemokine and growth factor functions. Although the exact mechanisms of HMGB1 in pancreatic cancer are still to be elucidated, the significance of this protein for processes, such as autophagy, immunogenic cell death, tumor growth, metastasis and resistance to chemotherapy, have become increasingly clear. In this review, we provide a systematic summary and review of the biological and clinical relevance of HMGB1 in pancreatic cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarker, HMGB1, Pancreatic cancer, Review, Tumor promoter, Tumor suppressor
in
Anticancer Research
volume
36
issue
9
pages
10 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:84991619097
  • wos:000384001800001
ISSN
0250-7005
DOI
10.21873/anticanres.10981
language
English
LU publication?
yes
id
9edcc2ce-64ad-4947-8ef6-d62ef1d64673
date added to LUP
2016-11-04 09:34:59
date last changed
2017-09-18 11:29:17
@article{9edcc2ce-64ad-4947-8ef6-d62ef1d64673,
  abstract     = {<p>Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabilizing the genome, whereas extracellular HMGB1 behaves as a protumor protein with cytokine, chemokine and growth factor functions. Although the exact mechanisms of HMGB1 in pancreatic cancer are still to be elucidated, the significance of this protein for processes, such as autophagy, immunogenic cell death, tumor growth, metastasis and resistance to chemotherapy, have become increasingly clear. In this review, we provide a systematic summary and review of the biological and clinical relevance of HMGB1 in pancreatic cancer.</p>},
  author       = {Cebrián, María José García and Bauden, Monika and Andersson, Roland and Holdenrieder, Stefan and Ansari, Daniel},
  issn         = {0250-7005},
  keyword      = {Biomarker,HMGB1,Pancreatic cancer,Review,Tumor promoter,Tumor suppressor},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {4381--4390},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Paradoxical role of hmgb1 in pancreatic cancer : Tumor suppressor or tumor promoter?},
  url          = {http://dx.doi.org/10.21873/anticanres.10981},
  volume       = {36},
  year         = {2016},
}