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The incidence of Parkinson's disease in the North-East of England

Duncan, Gordon William; Khoo, Tien Kheng; Coleman, Shirley Y; Brayne, Carol; Yarnall, Alison Jane; O'Brien, John Tiernan; Barker, Roger A LU and Burn, David J (2014) In Age and Ageing 43(2). p.63-257
Abstract

BACKGROUND: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research.

OBJECTIVE: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England.

METHODS: using a prospective, longitudinal design, we sought to identify every new case of Parkinson's disease arising in the Newcastle and Gateshead area in the North-East of England. The base population comprised 488 576 individuals and multiple sources of case ascertainment were employed. All the patients with newly diagnosed idiopathic Parkinson's disease or... (More)

BACKGROUND: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research.

OBJECTIVE: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England.

METHODS: using a prospective, longitudinal design, we sought to identify every new case of Parkinson's disease arising in the Newcastle and Gateshead area in the North-East of England. The base population comprised 488 576 individuals and multiple sources of case ascertainment were employed. All the patients with newly diagnosed idiopathic Parkinson's disease or parkinsonism between 1 June 2009 and 31 May 2011 were invited to participate. Patients were examined by a specialist and followed longitudinally to permit diagnostic review.

RESULTS: we identified 257 potential cases, of whom 181 had suspected idiopathic Parkinson's disease. After a follow-up period of 18 months, 155 patients retained a clinical diagnosis of probable Parkinson's disease. The mean age at diagnosis was 72.4 ± 10 years. The crude incidence of PD in Newcastle and Gateshead was 15.9 per 100 000 persons per year (95% CI: 13.4-18.4). Age-standardised to the European population the incidence of Parkinson's disease was 12.0 per 100 000 (95% CI: 10.1-14.0). We found a higher crude incidence among men 17.7 per 100 000 (95% CI: 14.0-21.4) than women 14.0 per 100 000 (95% CI: 10.7-17.4).

CONCLUSION: in this prospective longitudinal study, the incidence rate of Parkinson's disease in North-East England is similar to that of other modern European and American studies.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age Distribution, Age Factors, Aged, Aged, 80 and over, England, Female, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Prospective Studies, Sex Distribution, Sex Factors, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
in
Age and Ageing
volume
43
issue
2
pages
63 - 257
publisher
Oxford University Press
external identifiers
  • scopus:84896720184
ISSN
1468-2834
DOI
10.1093/ageing/aft091
language
English
LU publication?
no
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9ee70697-92a2-4442-a5fa-c392340ca946
date added to LUP
2016-11-24 15:18:05
date last changed
2017-04-23 04:55:21
@article{9ee70697-92a2-4442-a5fa-c392340ca946,
  abstract     = {<p>BACKGROUND: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research.</p><p>OBJECTIVE: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England.</p><p>METHODS: using a prospective, longitudinal design, we sought to identify every new case of Parkinson's disease arising in the Newcastle and Gateshead area in the North-East of England. The base population comprised 488 576 individuals and multiple sources of case ascertainment were employed. All the patients with newly diagnosed idiopathic Parkinson's disease or parkinsonism between 1 June 2009 and 31 May 2011 were invited to participate. Patients were examined by a specialist and followed longitudinally to permit diagnostic review.</p><p>RESULTS: we identified 257 potential cases, of whom 181 had suspected idiopathic Parkinson's disease. After a follow-up period of 18 months, 155 patients retained a clinical diagnosis of probable Parkinson's disease. The mean age at diagnosis was 72.4 ± 10 years. The crude incidence of PD in Newcastle and Gateshead was 15.9 per 100 000 persons per year (95% CI: 13.4-18.4). Age-standardised to the European population the incidence of Parkinson's disease was 12.0 per 100 000 (95% CI: 10.1-14.0). We found a higher crude incidence among men 17.7 per 100 000 (95% CI: 14.0-21.4) than women 14.0 per 100 000 (95% CI: 10.7-17.4).</p><p>CONCLUSION: in this prospective longitudinal study, the incidence rate of Parkinson's disease in North-East England is similar to that of other modern European and American studies.</p>},
  author       = {Duncan, Gordon William and Khoo, Tien Kheng and Coleman, Shirley Y and Brayne, Carol and Yarnall, Alison Jane and O'Brien, John Tiernan and Barker, Roger A and Burn, David J},
  issn         = {1468-2834},
  keyword      = {Age Distribution,Age Factors,Aged,Aged, 80 and over,England,Female,Humans,Incidence,Longitudinal Studies,Male,Middle Aged,Parkinson Disease,Prospective Studies,Sex Distribution,Sex Factors,Time Factors,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {63--257},
  publisher    = {Oxford University Press},
  series       = {Age and Ageing},
  title        = {The incidence of Parkinson's disease in the North-East of England},
  url          = {http://dx.doi.org/10.1093/ageing/aft091},
  volume       = {43},
  year         = {2014},
}