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GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population

Brolin, Kajsa Atterling LU orcid ; Bäckström, David ; Wallenius, Joel LU orcid ; Gan-Or, Ziv ; Puschmann, Andreas LU orcid ; Hansson, Oskar LU orcid and Swanberg, Maria LU (2025) In Parkinsonism and Related Disorders 130.
Abstract

Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Parkinsonism and Related Disorders
volume
130
article number
107191
publisher
Elsevier
external identifiers
  • pmid:39514913
  • scopus:85208201476
ISSN
1353-8020
DOI
10.1016/j.parkreldis.2024.107191
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2024 The Authors
id
9f11f594-d59a-40ad-a0c0-cd1a07b6cf8c
date added to LUP
2025-01-13 10:41:04
date last changed
2025-07-01 00:38:39
@article{9f11f594-d59a-40ad-a0c0-cd1a07b6cf8c,
  abstract     = {{<p>Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.</p>}},
  author       = {{Brolin, Kajsa Atterling and Bäckström, David and Wallenius, Joel and Gan-Or, Ziv and Puschmann, Andreas and Hansson, Oskar and Swanberg, Maria}},
  issn         = {{1353-8020}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Parkinsonism and Related Disorders}},
  title        = {{GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population}},
  url          = {{http://dx.doi.org/10.1016/j.parkreldis.2024.107191}},
  doi          = {{10.1016/j.parkreldis.2024.107191}},
  volume       = {{130}},
  year         = {{2025}},
}