Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study
(2021) In Diabetes 70(9). p.2092-2106- Abstract
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control... (More)
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2021-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 70
- issue
- 9
- pages
- 15 pages
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- scopus:85115388774
- pmid:34233929
- ISSN
- 1939-327X
- DOI
- 10.2337/db21-0227
- language
- English
- LU publication?
- yes
- id
- 9f3aa9fd-f216-42c1-9533-f1717c9765d6
- date added to LUP
- 2022-03-18 16:00:58
- date last changed
- 2024-04-18 06:30:23
@article{9f3aa9fd-f216-42c1-9533-f1717c9765d6,
abstract = {{<p>Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.</p>}},
author = {{Tura, Andrea and Grespan, Eleonora and Göbl, Christian S. and Koivula, Robert W. and Franks, Paul W. and Pearson, Ewan R. and Walker, Mark and Forgie, Ian M. and Giordano, Giuseppe N. and Pavo, Imre and Ruetten, Hartmut and Dermitzakis, Emmanouil T. and McCarthy, Mark I. and Pedersen, Oluf and Schwenk, Jochen M. and Adamski, Jerzy and De Masi, Federico and Tsirigos, Konstantinos D. and Brunak, Søren and Viñuela, Ana and Mahajan, Anubha and McDonald, Timothy J. and Kokkola, Tarja and Vangipurapu, Jagadish and Cederberg, Henna and Laakso, Markku and Rutters, Femke and Elders, Petra J.M. and Koopman, Anitra D.M. and Beulens, Joline W. and Ridderstråle, Martin and Hansen, Tue H. and Allin, Kristine H. and Hansen, Torben and Vestergaard, Henrik and Mari, Andrea}},
issn = {{1939-327X}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{2092--2106}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study}},
url = {{http://dx.doi.org/10.2337/db21-0227}},
doi = {{10.2337/db21-0227}},
volume = {{70}},
year = {{2021}},
}