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Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study

Tura, Andrea ; Grespan, Eleonora ; Göbl, Christian S. ; Koivula, Robert W. LU ; Franks, Paul W. LU ; Pearson, Ewan R. LU ; Walker, Mark ; Forgie, Ian M. ; Giordano, Giuseppe N. LU and Pavo, Imre , et al. (2021) In Diabetes 70(9). p.2092-2106
Abstract

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control... (More)

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
70
issue
9
pages
15 pages
publisher
American Diabetes Association Inc.
external identifiers
  • pmid:34233929
  • scopus:85115388774
ISSN
1939-327X
DOI
10.2337/db21-0227
language
English
LU publication?
yes
id
9f3aa9fd-f216-42c1-9533-f1717c9765d6
date added to LUP
2022-03-18 16:00:58
date last changed
2024-11-01 02:14:11
@article{9f3aa9fd-f216-42c1-9533-f1717c9765d6,
  abstract     = {{<p>Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P &lt; 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P &lt; 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio &gt;2, P &lt; 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.</p>}},
  author       = {{Tura, Andrea and Grespan, Eleonora and Göbl, Christian S. and Koivula, Robert W. and Franks, Paul W. and Pearson, Ewan R. and Walker, Mark and Forgie, Ian M. and Giordano, Giuseppe N. and Pavo, Imre and Ruetten, Hartmut and Dermitzakis, Emmanouil T. and McCarthy, Mark I. and Pedersen, Oluf and Schwenk, Jochen M. and Adamski, Jerzy and De Masi, Federico and Tsirigos, Konstantinos D. and Brunak, Søren and Viñuela, Ana and Mahajan, Anubha and McDonald, Timothy J. and Kokkola, Tarja and Vangipurapu, Jagadish and Cederberg, Henna and Laakso, Markku and Rutters, Femke and Elders, Petra J.M. and Koopman, Anitra D.M. and Beulens, Joline W. and Ridderstråle, Martin and Hansen, Tue H. and Allin, Kristine H. and Hansen, Torben and Vestergaard, Henrik and Mari, Andrea}},
  issn         = {{1939-327X}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{2092--2106}},
  publisher    = {{American Diabetes Association Inc.}},
  series       = {{Diabetes}},
  title        = {{Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT : An IMI DIRECT Study}},
  url          = {{http://dx.doi.org/10.2337/db21-0227}},
  doi          = {{10.2337/db21-0227}},
  volume       = {{70}},
  year         = {{2021}},
}