Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia : Results from the Betula Cohort in Northern Sweden
(2021) In Journal of Alzheimer's Disease 81(1). p.83-85- Abstract
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1µg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they... (More)
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1µg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.
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- author
- Aström, Daniel Oudin LU ; Adolfsson, Rolf ; Segersson, David ; Forsberg, Bertil and Oudin, Anna LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Air pollution, Alzheimer's disease, dementia, particulate air pollution, PM
- in
- Journal of Alzheimer's Disease
- volume
- 81
- issue
- 1
- pages
- 3 pages
- publisher
- IOS Press
- external identifiers
-
- scopus:85105728122
- pmid:33749652
- ISSN
- 1387-2877
- DOI
- 10.3233/JAD-201538
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: This work was supported by Swedish Research Council Formas under grant agreement number 2017-00898 (AO).
- id
- 9f4758c7-29f9-4de1-b5ee-01a67a544c22
- date added to LUP
- 2021-06-07 15:09:55
- date last changed
- 2024-06-15 12:10:44
@article{9f4758c7-29f9-4de1-b5ee-01a67a544c22,
abstract = {{<p>Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1µg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting. </p>}},
author = {{Aström, Daniel Oudin and Adolfsson, Rolf and Segersson, David and Forsberg, Bertil and Oudin, Anna}},
issn = {{1387-2877}},
keywords = {{Air pollution; Alzheimer's disease; dementia; particulate air pollution; PM}},
language = {{eng}},
number = {{1}},
pages = {{83--85}},
publisher = {{IOS Press}},
series = {{Journal of Alzheimer's Disease}},
title = {{Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM<sub>2.5</sub>) and Incidence of Alzheimer's Disease and Dementia : Results from the Betula Cohort in Northern Sweden}},
url = {{http://dx.doi.org/10.3233/JAD-201538}},
doi = {{10.3233/JAD-201538}},
volume = {{81}},
year = {{2021}},
}