A link between Krüppel-like factor 4, complement activation, and kidney damage
(2022) In Kidney International 102(1). p.14-16- Abstract
Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9f9ec7ca-245d-416d-b138-93c13a0b186b
- author
- Karpman, Diana LU and Loos, Sebastian LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Kidney International
- volume
- 102
- issue
- 1
- pages
- 3 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:35738827
- scopus:85132219954
- ISSN
- 0085-2538
- DOI
- 10.1016/j.kint.2022.04.014
- language
- English
- LU publication?
- yes
- id
- 9f9ec7ca-245d-416d-b138-93c13a0b186b
- date added to LUP
- 2022-08-26 15:55:24
- date last changed
- 2024-09-05 16:37:53
@misc{9f9ec7ca-245d-416d-b138-93c13a0b186b, abstract = {{<p>Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.</p>}}, author = {{Karpman, Diana and Loos, Sebastian}}, issn = {{0085-2538}}, language = {{eng}}, number = {{1}}, pages = {{14--16}}, publisher = {{Nature Publishing Group}}, series = {{Kidney International}}, title = {{A link between Krüppel-like factor 4, complement activation, and kidney damage}}, url = {{http://dx.doi.org/10.1016/j.kint.2022.04.014}}, doi = {{10.1016/j.kint.2022.04.014}}, volume = {{102}}, year = {{2022}}, }