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A link between Krüppel-like factor 4, complement activation, and kidney damage

Karpman, Diana LU orcid and Loos, Sebastian LU (2022) In Kidney International 102(1). p.14-16
Abstract

Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Kidney International
volume
102
issue
1
pages
3 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85132219954
  • pmid:35738827
ISSN
0085-2538
DOI
10.1016/j.kint.2022.04.014
language
English
LU publication?
yes
id
9f9ec7ca-245d-416d-b138-93c13a0b186b
date added to LUP
2022-08-26 15:55:24
date last changed
2024-06-27 09:55:38
@misc{9f9ec7ca-245d-416d-b138-93c13a0b186b,
  abstract     = {{<p>Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.</p>}},
  author       = {{Karpman, Diana and Loos, Sebastian}},
  issn         = {{0085-2538}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{14--16}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Kidney International}},
  title        = {{A link between Krüppel-like factor 4, complement activation, and kidney damage}},
  url          = {{http://dx.doi.org/10.1016/j.kint.2022.04.014}},
  doi          = {{10.1016/j.kint.2022.04.014}},
  volume       = {{102}},
  year         = {{2022}},
}