Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution
Woych, Jamie ; Ortega Gurrola, Alonso ; Deryckere, Astrid ; Jaeger, Eliza C B ; Gumnit, Elias ; Merello, Gianluca ; Gu, Jiacheng ; Joven Araus, Alberto ; Leigh, Nicholas D LU
and Yun, Maximina
, et al.
(2022)
In Science (New York, N.Y.)
377(6610).
p.1-11
- Abstract
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander
Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and... (More)The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander
(Less)
Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.
- author
- Woych, Jamie
; Ortega Gurrola, Alonso
; Deryckere, Astrid
; Jaeger, Eliza C B
; Gumnit, Elias
; Merello, Gianluca
; Gu, Jiacheng
; Joven Araus, Alberto
; Leigh, Nicholas D
LU
and Yun, Maximina
, et al. (More)
- Woych, Jamie
; Ortega Gurrola, Alonso
; Deryckere, Astrid
; Jaeger, Eliza C B
; Gumnit, Elias
; Merello, Gianluca
; Gu, Jiacheng
; Joven Araus, Alberto
; Leigh, Nicholas D
LU
; Yun, Maximina
; Simon, András
and Tosches, Maria Antonietta
(Less)
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Atlases as Topic, Biological Evolution, Neocortex/cytology, Neurons/metabolism, Pleurodeles/physiology, Telencephalon/cytology, Transcriptome
- in
- Science (New York, N.Y.)
- volume
- 377
- issue
- 6610
- article number
- eabp9186
- pages
- 1 - 11
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:85137115575
- pmid:36048957
- ISSN
- 1095-9203
- DOI
- 10.1126/science.abp9186
- language
- English
- LU publication?
- yes
- id
- 9fdd9415-5467-40bd-bc30-3aed6a2452a7
- date added to LUP
- 2022-09-27 13:27:56
- date last changed
- 2025-02-07 20:13:45
@article{9fdd9415-5467-40bd-bc30-3aed6a2452a7,
abstract = {{<p>The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander <br>
Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.<br>
</p>}},
author = {{Woych, Jamie and Ortega Gurrola, Alonso and Deryckere, Astrid and Jaeger, Eliza C B and Gumnit, Elias and Merello, Gianluca and Gu, Jiacheng and Joven Araus, Alberto and Leigh, Nicholas D and Yun, Maximina and Simon, András and Tosches, Maria Antonietta}},
issn = {{1095-9203}},
keywords = {{Animals; Atlases as Topic; Biological Evolution; Neocortex/cytology; Neurons/metabolism; Pleurodeles/physiology; Telencephalon/cytology; Transcriptome}},
language = {{eng}},
number = {{6610}},
pages = {{1--11}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science (New York, N.Y.)}},
title = {{Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution}},
url = {{http://dx.doi.org/10.1126/science.abp9186}},
doi = {{10.1126/science.abp9186}},
volume = {{377}},
year = {{2022}},
}