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Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Woych, Jamie ; Gurrola, Alonso Ortega ; Deryckere, Astrid ; Jaeger, Eliza C. B. ; Gumnit, Elias ; Merello, Gianluca ; Gu, Jiacheng ; Araus, Alberto Joven ; Leigh, Nicholas D. LU orcid and Yun, Maximina , et al. (2022)
Abstract
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these novelties arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell type atlas of the telencephalon of the salamander Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. In contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex, yet shares similarities with entorhinal cortex and subiculum. Our... (More)
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these novelties arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell type atlas of the telencephalon of the salamander Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. In contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex, yet shares similarities with entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the sauropsid DVR, and the mammalian six-layered neocortex. (Less)
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type
Working paper/Preprint
publication status
published
subject
publisher
bioRxiv
DOI
10.1101/2022.03.28.485354
language
English
LU publication?
yes
id
dfb4c950-476e-4d7f-b511-d6cfdb374fbb
date added to LUP
2025-10-23 09:40:10
date last changed
2025-10-23 09:44:16
@misc{dfb4c950-476e-4d7f-b511-d6cfdb374fbb,
  abstract     = {{The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these novelties arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell type atlas of the telencephalon of the salamander Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. In contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex, yet shares similarities with entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the sauropsid DVR, and the mammalian six-layered neocortex.}},
  author       = {{Woych, Jamie and Gurrola, Alonso Ortega and Deryckere, Astrid and Jaeger, Eliza C. B. and Gumnit, Elias and Merello, Gianluca and Gu, Jiacheng and Araus, Alberto Joven and Leigh, Nicholas D. and Yun, Maximina and Simon, András and Tosches, Maria Antonietta}},
  language     = {{eng}},
  month        = {{03}},
  note         = {{Preprint}},
  publisher    = {{bioRxiv}},
  title        = {{Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution}},
  url          = {{http://dx.doi.org/10.1101/2022.03.28.485354}},
  doi          = {{10.1101/2022.03.28.485354}},
  year         = {{2022}},
}