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Insulin Pump Therapy and Adverse Skin Reactions With Focus on Allergic Contact Dermatitis in Individuals Living With Diabetes Mellitus : A Systematic Review and Clinical-Based Update

von Kobyletzki, Laura Beate LU ; Ulriksdotter, Josefin LU orcid ; von Kobyletzki, Elisa LU ; Mowitz, Martin LU ; Jendle, Johan and Svedman, Cecilia LU (2024) In Journal of diabetes science and technology 18(6). p.1300-1312
Abstract

Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA)... (More)

Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA) was also performed highlighting the diagnostic process. Results: Among the 391 screened abstracts, 21 studies fulfilled the inclusion criteria. Seven studies included data on children only, four studies were on adults, and nine studies reported data on both children and adults. Participants were exposed to a broad range of pumps. Dermatitis was rarely specified. Up to 60% of those referred to a university hospital due to skin reactions possibly related to insulin pumps had an ACD. Conclusions: The review and our findings indicate that there is not sufficient focus on contact allergy in the primary toxicological evaluations of substances used also for insulin pump therapy products and that possible adverse skin reactions are not correctly followed up in the clinical setting.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic, contact, dermatitis, diabetes mellitus, insulin infusion systems, insulin-dependent, prevalence, systematic review
in
Journal of diabetes science and technology
volume
18
issue
6
pages
1300 - 1312
publisher
Diabetes Technology Society
external identifiers
  • pmid:38853748
  • scopus:85195918849
ISSN
1932-2968
DOI
10.1177/19322968241252613
language
English
LU publication?
yes
id
a0388de6-0625-4fbe-9424-898197210f73
date added to LUP
2024-09-11 14:10:28
date last changed
2024-12-19 02:10:35
@article{a0388de6-0625-4fbe-9424-898197210f73,
  abstract     = {{<p>Background: The use of insulin pumps (continuous subcutaneous insulin infusion [CSII]) in individuals living with type 1 diabetes (T1D) improves disease control. However, adverse skin reactions may hamper compliance. We aimed to assess the relationship of insulin pumps, particularly that of infusion set therapy, used in children and adults with T1D and dermatitis including allergic contact dermatitis (ACD). Methods: A systematic search of PubMed, and EMBASE, of full-text studies reporting dermatitis in persons with diabetes using a CSII was conducted from 2020 to 2023. The Newcastle-Ottawa Scale was used to assess study quality. The inventory performed at the Department of Occupational and Environmental Dermatology, Malmö, Sweden (YMDA) was also performed highlighting the diagnostic process. Results: Among the 391 screened abstracts, 21 studies fulfilled the inclusion criteria. Seven studies included data on children only, four studies were on adults, and nine studies reported data on both children and adults. Participants were exposed to a broad range of pumps. Dermatitis was rarely specified. Up to 60% of those referred to a university hospital due to skin reactions possibly related to insulin pumps had an ACD. Conclusions: The review and our findings indicate that there is not sufficient focus on contact allergy in the primary toxicological evaluations of substances used also for insulin pump therapy products and that possible adverse skin reactions are not correctly followed up in the clinical setting.</p>}},
  author       = {{von Kobyletzki, Laura Beate and Ulriksdotter, Josefin and von Kobyletzki, Elisa and Mowitz, Martin and Jendle, Johan and Svedman, Cecilia}},
  issn         = {{1932-2968}},
  keywords     = {{allergic; contact; dermatitis; diabetes mellitus; insulin infusion systems; insulin-dependent; prevalence; systematic review}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1300--1312}},
  publisher    = {{Diabetes Technology Society}},
  series       = {{Journal of diabetes science and technology}},
  title        = {{Insulin Pump Therapy and Adverse Skin Reactions With Focus on Allergic Contact Dermatitis in Individuals Living With Diabetes Mellitus : A Systematic Review and Clinical-Based Update}},
  url          = {{http://dx.doi.org/10.1177/19322968241252613}},
  doi          = {{10.1177/19322968241252613}},
  volume       = {{18}},
  year         = {{2024}},
}