Advanced

Cancers in the first-degree relatives of children with brain tumours

Hemminki, K LU ; Li, Xinjun LU ; Vaittinen, P and Dong, C (2000) In British Journal of Cancer 83(3). p.11-407
Abstract

We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental... (More)

We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Astrocytoma/epidemiology, Brain Neoplasms/epidemiology, Child, Child, Preschool, Databases, Factual, Ependymoma/epidemiology, Female, Humans, Incidence, Male, Medulloblastoma/epidemiology, Middle Aged, Nuclear Family, Sweden/epidemiology
in
British Journal of Cancer
volume
83
issue
3
pages
5 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0033917820
ISSN
0007-0920
DOI
10.1054/bjoc.2000.1252
language
English
LU publication?
no
id
a03af50f-fa4e-452b-8118-1413a3969791
date added to LUP
2019-01-30 12:17:48
date last changed
2019-02-20 11:46:05
@article{a03af50f-fa4e-452b-8118-1413a3969791,
  abstract     = {<p>We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages &lt; 5 and &lt; 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61.</p>},
  author       = {Hemminki, K and Li, Xinjun and Vaittinen, P and Dong, C},
  issn         = {0007-0920},
  keyword      = {Adolescent,Adult,Astrocytoma/epidemiology,Brain Neoplasms/epidemiology,Child,Child, Preschool,Databases, Factual,Ependymoma/epidemiology,Female,Humans,Incidence,Male,Medulloblastoma/epidemiology,Middle Aged,Nuclear Family,Sweden/epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {11--407},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Cancers in the first-degree relatives of children with brain tumours},
  url          = {http://dx.doi.org/10.1054/bjoc.2000.1252},
  volume       = {83},
  year         = {2000},
}