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Proliferative activity and number of clonal chromosome aberrations in non‐Hodgkin's lymphomas

Brandt, Lars; Kristoffersson, Ulf LU and Olsson, Håkan LU (1986) In Scandinavian Journal of Haematology1964-01-01+01:001987-01-01+01:00 37(2). p.106-110
Abstract

Thymidine labelling indices (LI) and the number of clonal chromosome aberrations were assessed in fine‐needle aspirates from enlarged lymph nodes in 22 patients with non‐Hodgkin's lymphoma (NHL). 11 patients had LI > 3.0 (median 8.4) and 11 others had LI < 3.0 (median 1.0). Three categories of chromosome aberration were recorded: normal karyotype, 1–5 aberrations, and ≥ 6 aberrations or multiple complex changes. The distribution of these categories was different among the patients with LI > 3.0 compared to those with LI < 3.0 (p = 0.02). 8 of 11 patients with LI > 3.0 had ≥ 6 or complex changes. The corresponding figures for patients with LI < 3.0 were 2 out of 11. When 16 previously untreated patients were analysed... (More)

Thymidine labelling indices (LI) and the number of clonal chromosome aberrations were assessed in fine‐needle aspirates from enlarged lymph nodes in 22 patients with non‐Hodgkin's lymphoma (NHL). 11 patients had LI > 3.0 (median 8.4) and 11 others had LI < 3.0 (median 1.0). Three categories of chromosome aberration were recorded: normal karyotype, 1–5 aberrations, and ≥ 6 aberrations or multiple complex changes. The distribution of these categories was different among the patients with LI > 3.0 compared to those with LI < 3.0 (p = 0.02). 8 of 11 patients with LI > 3.0 had ≥ 6 or complex changes. The corresponding figures for patients with LI < 3.0 were 2 out of 11. When 16 previously untreated patients were analysed separately, the median number of clonal aberrations was 6.5 in 8 patients with LI > 3.0 and 2.5 in 8 others with LI < 3.0 (p = 0.025). The results suggest that early and spontaneous changes in the genetic material are common in lymphomas with a high proliferative activity. According to previous studies, therapeutic results are especially poor in NHL with high LI. It is proposed that a high proliferative activity of lymphoma cells facilitates an early development of several new mutants and that some of these may be resistant to chemotherapeutic agents.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
chromosome aberrations, labelling index, non‐Hodgkin's lymphoma
in
Scandinavian Journal of Haematology1964-01-01+01:001987-01-01+01:00
volume
37
issue
2
pages
106 - 110
publisher
Wiley-Blackwell
external identifiers
  • scopus:0022916454
ISSN
0036-553X
DOI
10.1111/j.1600-0609.1986.tb01782.x
language
English
LU publication?
yes
id
a059ea8a-d195-46ba-9c3e-ce842aa45142
date added to LUP
2018-12-17 12:43:12
date last changed
2019-01-06 14:20:04
@article{a059ea8a-d195-46ba-9c3e-ce842aa45142,
  abstract     = {<p>Thymidine labelling indices (LI) and the number of clonal chromosome aberrations were assessed in fine‐needle aspirates from enlarged lymph nodes in 22 patients with non‐Hodgkin's lymphoma (NHL). 11 patients had LI &gt; 3.0 (median 8.4) and 11 others had LI &lt; 3.0 (median 1.0). Three categories of chromosome aberration were recorded: normal karyotype, 1–5 aberrations, and ≥ 6 aberrations or multiple complex changes. The distribution of these categories was different among the patients with LI &gt; 3.0 compared to those with LI &lt; 3.0 (p = 0.02). 8 of 11 patients with LI &gt; 3.0 had ≥ 6 or complex changes. The corresponding figures for patients with LI &lt; 3.0 were 2 out of 11. When 16 previously untreated patients were analysed separately, the median number of clonal aberrations was 6.5 in 8 patients with LI &gt; 3.0 and 2.5 in 8 others with LI &lt; 3.0 (p = 0.025). The results suggest that early and spontaneous changes in the genetic material are common in lymphomas with a high proliferative activity. According to previous studies, therapeutic results are especially poor in NHL with high LI. It is proposed that a high proliferative activity of lymphoma cells facilitates an early development of several new mutants and that some of these may be resistant to chemotherapeutic agents.</p>},
  author       = {Brandt, Lars and Kristoffersson, Ulf and Olsson, Håkan},
  issn         = {0036-553X},
  keyword      = {chromosome aberrations,labelling index,non‐Hodgkin's lymphoma},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {106--110},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Haematology1964-01-01+01:001987-01-01+01:00},
  title        = {Proliferative activity and number of clonal chromosome aberrations in non‐Hodgkin's lymphomas},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.1986.tb01782.x},
  volume       = {37},
  year         = {1986},
}