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Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden

Li, Xinjun LU ; Sjöstedt, Cecilia LU ; Sundquist, Jan LU ; Zöller, Bengt LU and Sundquist, Kristina LU (2019) In Psychiatric Genetics 29(2). p.37-43
Abstract

AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.

PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. An open cohort design of the diseases in individual and family members was obtained through linkage to the Hospital Discharge Register. Standardized incidence ratios were calculated as relative risks for ADHD in family members of affected patients compared with those without affected... (More)

AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.

PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. An open cohort design of the diseases in individual and family members was obtained through linkage to the Hospital Discharge Register. Standardized incidence ratios were calculated as relative risks for ADHD in family members of affected patients compared with those without affected family members.

RESULTS: Among a total of 86 493 patients, 18 153 had a family history of autoimmune diseases. ADHD was associated with 14 autoimmune diseases in the first-degree relatives, including ankylosing spondylitis (standardized incidence ratio:1.13), celiac disease (1.16), Crohn's disease (1.07), diabetes mellitus type 1 (1.19), discoid lupus erythematosus (1.26), glomerular nephritis chronic (1.13), Hashimoto/hypothyroidism (1.11), lupoid hepatitis (1.44), multiple sclerosis (1.11), psoriasis (1.18), Reiter's disease (1.38), rheumatoid arthritis (1.07), Sjögren's syndrome (1.21), and ulcerative colitis (1.05).

CONCLUSIONS: Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatric Genetics
volume
29
issue
2
pages
37 - 43
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85062057458
ISSN
1473-5873
DOI
10.1097/YPG.0000000000000212
language
English
LU publication?
yes
id
a05a5038-7812-4a92-8de6-72e7f37c918c
date added to LUP
2019-01-30 10:44:49
date last changed
2019-03-17 05:12:25
@article{a05a5038-7812-4a92-8de6-72e7f37c918c,
  abstract     = {<p>AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.</p><p>PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. An open cohort design of the diseases in individual and family members was obtained through linkage to the Hospital Discharge Register. Standardized incidence ratios were calculated as relative risks for ADHD in family members of affected patients compared with those without affected family members.</p><p>RESULTS: Among a total of 86 493 patients, 18 153 had a family history of autoimmune diseases. ADHD was associated with 14 autoimmune diseases in the first-degree relatives, including ankylosing spondylitis (standardized incidence ratio:1.13), celiac disease (1.16), Crohn's disease (1.07), diabetes mellitus type 1 (1.19), discoid lupus erythematosus (1.26), glomerular nephritis chronic (1.13), Hashimoto/hypothyroidism (1.11), lupoid hepatitis (1.44), multiple sclerosis (1.11), psoriasis (1.18), Reiter's disease (1.38), rheumatoid arthritis (1.07), Sjögren's syndrome (1.21), and ulcerative colitis (1.05).</p><p>CONCLUSIONS: Familial associations with several autoimmune diseases suggest genetic sharing and challenge to gene identification.</p>},
  author       = {Li, Xinjun and Sjöstedt, Cecilia and Sundquist, Jan and Zöller, Bengt and Sundquist, Kristina},
  issn         = {1473-5873},
  language     = {eng},
  number       = {2},
  pages        = {37--43},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Psychiatric Genetics},
  title        = {Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden},
  url          = {http://dx.doi.org/10.1097/YPG.0000000000000212},
  volume       = {29},
  year         = {2019},
}