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Intact endothelial and contractile function of coronary artery after 8 hours of heart preservation

Qin, Guangqi LU ; Sjöberg, Trygve LU ; Liao, Qiuming LU ; Sun, Xiaoke and Steen, Stig LU (2016) In Scandinavian Cardiovascular Journal 50(5-6). p.362-366
Abstract

Objectives. The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. Design. Porcine hearts were perfused for 8 hours at 8 °C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg. In organ baths, coronary artery segments from the preserved hearts were studied and compared to fresh controls. Results. Endothelium-dependent relaxation and contractility were fully preserved after both intermittent and continuous... (More)

Objectives. The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. Design. Porcine hearts were perfused for 8 hours at 8 °C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg. In organ baths, coronary artery segments from the preserved hearts were studied and compared to fresh controls. Results. Endothelium-dependent relaxation and contractility were fully preserved after both intermittent and continuous perfusion, as compared to fresh controls. No myocardial edema was seen; water content of the myocardium was 79.5 ± 0.2%, 79.0 ± 0.4% and 79.0 ± 0.3% (ns) for fresh controls, intermittently perfused, and continuously perfused hearts, respectively. Conclusion. Intact endothelial and contractile function of coronary artery may be obtained after 8 hours of non-ischemic heart preservation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary contractility, coronary endothelial function, Heart preservation
in
Scandinavian Cardiovascular Journal
volume
50
issue
5-6
pages
362 - 366
publisher
Taylor & Francis
external identifiers
  • scopus:84980360434
  • wos:000390105700018
ISSN
1401-7431
DOI
10.1080/14017431.2016.1213876
language
English
LU publication?
yes
id
a09ac973-3e3d-4f1a-abb1-2fda65486f86
date added to LUP
2016-08-19 15:57:09
date last changed
2017-09-18 11:28:39
@article{a09ac973-3e3d-4f1a-abb1-2fda65486f86,
  abstract     = {<p>Objectives. The aim of the study was to investigate if adequate preservation of coronary artery endothelium-dependent relaxation and contractility may be obtained after 8 hours of non-ischemic heart preservation. Design. Porcine hearts were perfused for 8 hours at 8 °C, either in cycles of 15 minutes perfusion and 60 minutes non-perfusion, or by continuous perfusion. The perfusate consisted of a cardioplegic, hyperoncotic nutrition solution with oxygenated red cells, and the perfusion pressure was 20 mmHg. In organ baths, coronary artery segments from the preserved hearts were studied and compared to fresh controls. Results. Endothelium-dependent relaxation and contractility were fully preserved after both intermittent and continuous perfusion, as compared to fresh controls. No myocardial edema was seen; water content of the myocardium was 79.5 ± 0.2%, 79.0 ± 0.4% and 79.0 ± 0.3% (ns) for fresh controls, intermittently perfused, and continuously perfused hearts, respectively. Conclusion. Intact endothelial and contractile function of coronary artery may be obtained after 8 hours of non-ischemic heart preservation.</p>},
  author       = {Qin, Guangqi and Sjöberg, Trygve and Liao, Qiuming and Sun, Xiaoke and Steen, Stig},
  issn         = {1401-7431},
  keyword      = {coronary contractility,coronary endothelial function,Heart preservation},
  language     = {eng},
  number       = {5-6},
  pages        = {362--366},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Intact endothelial and contractile function of coronary artery after 8 hours of heart preservation},
  url          = {http://dx.doi.org/10.1080/14017431.2016.1213876},
  volume       = {50},
  year         = {2016},
}