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Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy

Schmitt, Roland LU ; Lindahl, Gunnar LU and Karpman, Diana LU orcid (2010) In Nephrology Dialysis Transplantation 25(10). p.3434-3436
Abstract
Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IgA nephropathy, children, group A streptococci, M protein
in
Nephrology Dialysis Transplantation
volume
25
issue
10
pages
3434 - 3436
publisher
Oxford University Press
external identifiers
  • wos:000282172300048
  • scopus:77957225927
  • pmid:20558662
ISSN
1460-2385
DOI
10.1093/ndt/gfq346
language
English
LU publication?
yes
id
a19fdac0-485e-4623-97df-72a9aa15c329 (old id 1694587)
date added to LUP
2016-04-01 14:04:09
date last changed
2025-10-14 10:44:32
@article{a19fdac0-485e-4623-97df-72a9aa15c329,
  abstract     = {{Methods. Blood samples from patients with IgAN (n = 21) and age-matched controls (n = 83) were assayed by ELISA to detect an IgG antibody response to the IgA-BRs of the M4, M22 and M60 proteins. Antibodies were assayed for each IgA-BR separately and the results were combined. Results. Antibody levels to the IgA-BRs were significantly higher in IgAN patients than controls (P = 0.016), particularly in patients with recent streptococcal infection (P = 0.008). Conclusions. The results suggest that children with IgAN had a previous infection with a streptococcal strain expressing an IgA-binding M protein.}},
  author       = {{Schmitt, Roland and Lindahl, Gunnar and Karpman, Diana}},
  issn         = {{1460-2385}},
  keywords     = {{IgA nephropathy; children; group A streptococci; M protein}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{3434--3436}},
  publisher    = {{Oxford University Press}},
  series       = {{Nephrology Dialysis Transplantation}},
  title        = {{Antibody response to IgA-binding streptococcal M proteins in children with IgA nephropathy}},
  url          = {{http://dx.doi.org/10.1093/ndt/gfq346}},
  doi          = {{10.1093/ndt/gfq346}},
  volume       = {{25}},
  year         = {{2010}},
}