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The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Gradowski, Marcin and Pawlowski, Krzysztof LU (2017) In PeerJ 2017(9).
Abstract

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacterial effectors, Mitochondrial carriers, Proteases, Structure prediction
in
PeerJ
volume
2017
issue
9
publisher
PeerJ
external identifiers
  • scopus:85030092629
  • wos:000411715300003
ISSN
2167-8359
DOI
10.7717/peerj.3849
language
English
LU publication?
yes
id
a1a5a1a5-db2a-4004-a515-d4e2a4d9d33f
date added to LUP
2017-11-06 16:43:07
date last changed
2018-01-16 13:25:49
@article{a1a5a1a5-db2a-4004-a515-d4e2a4d9d33f,
  abstract     = {<p>Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.</p>},
  articleno    = {e3849},
  author       = {Gradowski, Marcin and Pawlowski, Krzysztof},
  issn         = {2167-8359},
  keyword      = {Bacterial effectors,Mitochondrial carriers,Proteases,Structure prediction},
  language     = {eng},
  number       = {9},
  publisher    = {PeerJ},
  series       = {PeerJ},
  title        = {The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases},
  url          = {http://dx.doi.org/10.7717/peerj.3849},
  volume       = {2017},
  year         = {2017},
}