Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Epidemiology and Pathogenesis of Type 1 Diabetes

Stene, Lars C. and Lernmark, Ake LU orcid (2023) p.13-39
Abstract
Type 1 diabetes is an autoimmune disease that affects 0.1 to nearly 1% of the population, dependent on the country, with its highest incidence around 10–15 years of age. The incidence has increased over time, approximately doubling over the past 2–3 decades. The incidence varies across the world, with the highest among populations of (Northern) European origin and the lowest in Japan. Most diabetic patients do not have affected first-degree relatives, but genetic predispostion encoded in the HLA class II DR- and DQ loci is proabably necessary, albeit not sufficient, for developing disease. Exposure to environmental factors in early life appears to also impact the risk of disease development, but available evidence does not allow for strong... (More)
Type 1 diabetes is an autoimmune disease that affects 0.1 to nearly 1% of the population, dependent on the country, with its highest incidence around 10–15 years of age. The incidence has increased over time, approximately doubling over the past 2–3 decades. The incidence varies across the world, with the highest among populations of (Northern) European origin and the lowest in Japan. Most diabetic patients do not have affected first-degree relatives, but genetic predispostion encoded in the HLA class II DR- and DQ loci is proabably necessary, albeit not sufficient, for developing disease. Exposure to environmental factors in early life appears to also impact the risk of disease development, but available evidence does not allow for strong conclusions to be drawn. The past decade has brought new data from human pancreatic donors. Hoewever, the timing between etiological triggers and the pathogenesis is poorly defined, and the disease mechanisms need to be elucidated. It is still not possible to prevent or cure type 1 diabetes. The latter can currently only be achieved using invasive beta-cell repacement therapies through transplantation. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Transplantation of the Pancreas
editor
Gruessner, Rainer W. G. and Gruessner, Angelika C.
edition
2
pages
13 - 39
ISBN
978-3-031-20999-4
978-3-031-20998-7
DOI
10.1007/978-3-031-20999-4_2
language
English
LU publication?
yes
id
a1c8f2ff-3d59-4234-b934-024f21e178e7
date added to LUP
2023-09-26 07:14:00
date last changed
2024-03-13 08:10:20
@inbook{a1c8f2ff-3d59-4234-b934-024f21e178e7,
  abstract     = {{Type 1 diabetes is an autoimmune disease that affects 0.1 to nearly 1% of the population, dependent on the country, with its highest incidence around 10–15 years of age. The incidence has increased over time, approximately doubling over the past 2–3 decades. The incidence varies across the world, with the highest among populations of (Northern) European origin and the lowest in Japan. Most diabetic patients do not have affected first-degree relatives, but genetic predispostion encoded in the HLA class II DR- and DQ loci is proabably necessary, albeit not sufficient, for developing disease. Exposure to environmental factors in early life appears to also impact the risk of disease development, but available evidence does not allow for strong conclusions to be drawn. The past decade has brought new data from human pancreatic donors. Hoewever, the timing between etiological triggers and the pathogenesis is poorly defined, and the disease mechanisms need to be elucidated. It is still not possible to prevent or cure type 1 diabetes. The latter can currently only be achieved using invasive beta-cell repacement therapies through transplantation.}},
  author       = {{Stene, Lars C. and Lernmark, Ake}},
  booktitle    = {{Transplantation of the Pancreas}},
  editor       = {{Gruessner, Rainer W. G. and Gruessner, Angelika C.}},
  isbn         = {{978-3-031-20999-4}},
  language     = {{eng}},
  pages        = {{13--39}},
  title        = {{Epidemiology and Pathogenesis of Type 1 Diabetes}},
  url          = {{http://dx.doi.org/10.1007/978-3-031-20999-4_2}},
  doi          = {{10.1007/978-3-031-20999-4_2}},
  year         = {{2023}},
}