Allelic polymorphism in MHC class IIB in four populations of Atlantic salmon (Salmo salar)
(2001) In Immunogenetics 53(4). p.329-336- Abstract
- We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by... (More)
- We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by allele frequency data. These results, together with the similarity found between exon 2 sequences from Baltic salmon and Norwegian salmon, indicate that all of the identified alleles were present in the ancient salmon population colonizing the Baltic rivers after the last glaciation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/145744
- author
- Langefors, Åsa LU ; Lohm, Jakob LU and von Schantz, Torbjörn LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunogenetics
- volume
- 53
- issue
- 4
- pages
- 329 - 336
- publisher
- Springer
- external identifiers
-
- scopus:0034911730
- ISSN
- 1432-1211
- DOI
- 10.1007/s002510100329
- language
- English
- LU publication?
- yes
- id
- a1d888fe-cd98-426d-a067-eabb47c1698d (old id 145744)
- date added to LUP
- 2016-04-01 11:43:14
- date last changed
- 2022-04-13 00:13:45
@article{a1d888fe-cd98-426d-a067-eabb47c1698d,
abstract = {{We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by allele frequency data. These results, together with the similarity found between exon 2 sequences from Baltic salmon and Norwegian salmon, indicate that all of the identified alleles were present in the ancient salmon population colonizing the Baltic rivers after the last glaciation.}},
author = {{Langefors, Åsa and Lohm, Jakob and von Schantz, Torbjörn}},
issn = {{1432-1211}},
language = {{eng}},
number = {{4}},
pages = {{329--336}},
publisher = {{Springer}},
series = {{Immunogenetics}},
title = {{Allelic polymorphism in MHC class IIB in four populations of Atlantic salmon (Salmo salar)}},
url = {{http://dx.doi.org/10.1007/s002510100329}},
doi = {{10.1007/s002510100329}},
volume = {{53}},
year = {{2001}},
}