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Physiological Role of TNF in Mucosal Immunology : Regulation of Macrophage/Dendritic Cell Function

Rivollier, Aymeric LU ; Marsal, J. LU and Agace, William W. LU (2015) In Frontiers of Gastrointestinal Research 34. p.9-26
Abstract

Intestinal mononuclear phagocytes, comprising macrophages (Mφs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor-α (TNF) in regulating multiple aspects of intestinal Mφ and DC physiology, including their differentiation, migration, maturation, survival and effector functions. In inflammatory bowel disease, TNF signaling has been implicated in reprogramming monocyte differentiation from the anti-inflammatory Mφ lineage towards the pro-inflammatory... (More)

Intestinal mononuclear phagocytes, comprising macrophages (Mφs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor-α (TNF) in regulating multiple aspects of intestinal Mφ and DC physiology, including their differentiation, migration, maturation, survival and effector functions. In inflammatory bowel disease, TNF signaling has been implicated in reprogramming monocyte differentiation from the anti-inflammatory Mφ lineage towards the pro-inflammatory mononuclear phagocyte lineage. These cells become a major source of TNF and, thus, may contribute to the chronic inflammatory process. Finally, we highlight some of the important gaps in our current knowledge regarding the role of TNF in Mφ and DC physiology and suggest important directions for future research in this field.

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author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease
series title
Frontiers of Gastrointestinal Research
editor
Rogler, G. ; Herfarth, H. ; Hibi, T. and Nielsen, O.H.
volume
34
pages
9 - 26
external identifiers
  • scopus:84937821466
ISSN
0302-0665
ISBN
978-3-318-05474-3
DOI
10.1159/000381381
language
English
LU publication?
yes
id
a2046f60-22b8-4c9b-915f-8eed411eb701
date added to LUP
2019-05-30 13:49:26
date last changed
2022-01-31 21:31:03
@inbook{a2046f60-22b8-4c9b-915f-8eed411eb701,
  abstract     = {{<p>Intestinal mononuclear phagocytes, comprising macrophages (Mφs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor-α (TNF) in regulating multiple aspects of intestinal Mφ and DC physiology, including their differentiation, migration, maturation, survival and effector functions. In inflammatory bowel disease, TNF signaling has been implicated in reprogramming monocyte differentiation from the anti-inflammatory Mφ lineage towards the pro-inflammatory mononuclear phagocyte lineage. These cells become a major source of TNF and, thus, may contribute to the chronic inflammatory process. Finally, we highlight some of the important gaps in our current knowledge regarding the role of TNF in Mφ and DC physiology and suggest important directions for future research in this field.</p>}},
  author       = {{Rivollier, Aymeric and Marsal, J. and Agace, William W.}},
  booktitle    = {{Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease}},
  editor       = {{Rogler, G. and Herfarth, H. and Hibi, T. and Nielsen, O.H.}},
  isbn         = {{978-3-318-05474-3}},
  issn         = {{0302-0665}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{9--26}},
  series       = {{Frontiers of Gastrointestinal Research}},
  title        = {{Physiological Role of TNF in Mucosal Immunology : Regulation of Macrophage/Dendritic Cell Function}},
  url          = {{http://dx.doi.org/10.1159/000381381}},
  doi          = {{10.1159/000381381}},
  volume       = {{34}},
  year         = {{2015}},
}