Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Regulation of human papillomavirus gene expression by splicing and polyadenylation.

Johansson, Cecilia LU and Schwartz, Stefan LU (2013) In Nature Reviews. Microbiology 11(4). p.239-251
Abstract
Human papillomaviruses (HPVs) are small DNA tumour viruses that are present in more than 99% of all cervical cancers. The ability of these viruses to cause disease is partly attributed to the strict coordination of viral gene expression with the differentiation stage of the infected cell. HPV gene expression is regulated temporally at the level of RNA splicing and polyadenylation, and a dysregulated gene expression programme allows some HPV types to establish long-term persistence, which is a risk factor for cancer. In this Review, we summarize the role of splicing and polyadenylation in the regulation of HPV gene expression and discuss the viral and cellular factors that control these processes.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Microbiology
volume
11
issue
4
pages
239 - 251
publisher
Nature Publishing Group
external identifiers
  • wos:000316778000012
  • pmid:23474685
  • scopus:84876418054
  • pmid:23474685
ISSN
1740-1534
DOI
10.1038/nrmicro2984
language
English
LU publication?
yes
id
a21f5265-f5e7-437b-b4b8-d6337f7800e4 (old id 3628360)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23474685?dopt=Abstract
date added to LUP
2016-04-01 11:07:12
date last changed
2022-04-20 17:11:35
@article{a21f5265-f5e7-437b-b4b8-d6337f7800e4,
  abstract     = {{Human papillomaviruses (HPVs) are small DNA tumour viruses that are present in more than 99% of all cervical cancers. The ability of these viruses to cause disease is partly attributed to the strict coordination of viral gene expression with the differentiation stage of the infected cell. HPV gene expression is regulated temporally at the level of RNA splicing and polyadenylation, and a dysregulated gene expression programme allows some HPV types to establish long-term persistence, which is a risk factor for cancer. In this Review, we summarize the role of splicing and polyadenylation in the regulation of HPV gene expression and discuss the viral and cellular factors that control these processes.}},
  author       = {{Johansson, Cecilia and Schwartz, Stefan}},
  issn         = {{1740-1534}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{239--251}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews. Microbiology}},
  title        = {{Regulation of human papillomavirus gene expression by splicing and polyadenylation.}},
  url          = {{http://dx.doi.org/10.1038/nrmicro2984}},
  doi          = {{10.1038/nrmicro2984}},
  volume       = {{11}},
  year         = {{2013}},
}