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Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.

Christoffersen, Stig LU ; Serra, Immacolata LU ; Terreni, M and Piskur, Jure LU (2010) In Nucleosides, Nucleotides & Nucleic Acids 29(4-6). p.445-448
Abstract
Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleosides, Nucleotides & Nucleic Acids
volume
29
issue
4-6
pages
445 - 448
publisher
Taylor & Francis
external identifiers
  • wos:000278713200031
  • scopus:77953692414
  • pmid:20544534
ISSN
1525-7770
DOI
10.1080/15257771003741422
language
English
LU publication?
yes
id
a225d8a3-cfad-451d-9b8e-bdcedd43db1b (old id 1626122)
date added to LUP
2016-04-01 10:26:21
date last changed
2022-04-27 22:03:01
@article{a225d8a3-cfad-451d-9b8e-bdcedd43db1b,
  abstract     = {{Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.}},
  author       = {{Christoffersen, Stig and Serra, Immacolata and Terreni, M and Piskur, Jure}},
  issn         = {{1525-7770}},
  language     = {{eng}},
  number       = {{4-6}},
  pages        = {{445--448}},
  publisher    = {{Taylor & Francis}},
  series       = {{Nucleosides, Nucleotides & Nucleic Acids}},
  title        = {{Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine.}},
  url          = {{http://dx.doi.org/10.1080/15257771003741422}},
  doi          = {{10.1080/15257771003741422}},
  volume       = {{29}},
  year         = {{2010}},
}