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Biochemical variables associated with bone density in patients with primary hyperparathyroidism

Bergenfelz, A LU ; Lindergård, B LU and Ahrén, B LU (1992) In European Journal of Surgery, Acta Chirurgica 158(9). p.6-473
Abstract

OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia.

DESIGN: Open study.

SETTING: Department of Surgery, University of Lund, Sweden.

SUBJECTS: 38 patients with primary hyperparathyroidism.

OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol.

RESULTS: There was no difference in bone density between men and women. There was no correlation between bone density and severity of... (More)

OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia.

DESIGN: Open study.

SETTING: Department of Surgery, University of Lund, Sweden.

SUBJECTS: 38 patients with primary hyperparathyroidism.

OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol.

RESULTS: There was no difference in bone density between men and women. There was no correlation between bone density and severity of hypercalcaemia or age. No biochemical abnormality was peculiar to the seven patients whose bone density was more than two SD below the population mean. Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin both correlated significantly with bone density (p < 0.05) and there was a strong correlation between serum osteocalcin and serum intact parathyroid hormone (p < 0.001). Serum osteocalcin had the strongest correlation with bone density of any of the biochemical variables.

CONCLUSION: There is little association between bone density and serum concentration of parathyroid hormone.

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keywords
Absorptiometry, Photon, Bone Density, Calcium, Cholecalciferol, Female, Humans, Hyperparathyroidism, Male, Middle Aged, Osteocalcin, Parathyroid Hormone, Journal Article, Research Support, Non-U.S. Gov't
in
European Journal of Surgery, Acta Chirurgica
volume
158
issue
9
pages
6 - 473
publisher
Taylor & Francis
external identifiers
  • scopus:0026669166
ISSN
1102-4151
language
English
LU publication?
yes
id
a23c206d-8d36-4ec7-adb6-69528bdf6305
date added to LUP
2017-05-10 17:48:38
date last changed
2017-08-09 09:17:58
@article{a23c206d-8d36-4ec7-adb6-69528bdf6305,
  abstract     = {<p>OBJECTIVE: To clarify the association between primary hyperparathyroidism and cortical osteopenia.</p><p>DESIGN: Open study.</p><p>SETTING: Department of Surgery, University of Lund, Sweden.</p><p>SUBJECTS: 38 patients with primary hyperparathyroidism.</p><p>OUTCOME MEASURES: Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol.</p><p>RESULTS: There was no difference in bone density between men and women. There was no correlation between bone density and severity of hypercalcaemia or age. No biochemical abnormality was peculiar to the seven patients whose bone density was more than two SD below the population mean. Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin both correlated significantly with bone density (p &lt; 0.05) and there was a strong correlation between serum osteocalcin and serum intact parathyroid hormone (p &lt; 0.001). Serum osteocalcin had the strongest correlation with bone density of any of the biochemical variables.</p><p>CONCLUSION: There is little association between bone density and serum concentration of parathyroid hormone.</p>},
  author       = {Bergenfelz, A and Lindergård, B and Ahrén, B},
  issn         = {1102-4151},
  keyword      = {Absorptiometry, Photon,Bone Density,Calcium,Cholecalciferol,Female,Humans,Hyperparathyroidism,Male,Middle Aged,Osteocalcin,Parathyroid Hormone,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {9},
  pages        = {6--473},
  publisher    = {Taylor & Francis},
  series       = {European Journal of Surgery, Acta Chirurgica},
  title        = {Biochemical variables associated with bone density in patients with primary hyperparathyroidism},
  volume       = {158},
  year         = {1992},
}