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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

Koivula, Robert LU ; Heggie, Alison ; Barnett, Anna ; Cederberg, Henna ; Hansen, Tue H ; Koopman, Anitra D ; Ridderstråle, Martin LU ; Rutters, Femke ; Vestergaard, Henrik and Gupta, Ramneek , et al. (2014) In Diabetologia 57(6). p.1132-1142
Abstract
The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
57
issue
6
pages
1132 - 1142
publisher
Springer
external identifiers
  • pmid:24695864
  • wos:000335922800006
  • scopus:84901229328
ISSN
1432-0428
DOI
10.1007/s00125-014-3216-x
language
English
LU publication?
yes
id
a23d1af8-b6e9-4f25-b9d9-388f6a45ccb7 (old id 4431161)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24695864?dopt=Abstract
date added to LUP
2016-04-01 10:30:21
date last changed
2022-04-04 18:41:43
@article{a23d1af8-b6e9-4f25-b9d9-388f6a45ccb7,
  abstract     = {{The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.}},
  author       = {{Koivula, Robert and Heggie, Alison and Barnett, Anna and Cederberg, Henna and Hansen, Tue H and Koopman, Anitra D and Ridderstråle, Martin and Rutters, Femke and Vestergaard, Henrik and Gupta, Ramneek and Herrgård, Sanna and Heymans, Martijn W and Perry, Mandy H and Rauh, Simone and Siloaho, Maritta and Teare, Harriet J A and Thorand, Barbara and Bell, Jimmy and Brunak, Søren and Frost, Gary and Jablonka, Bernd and Mari, Andrea and McDonald, Tim J and Dekker, Jacqueline M and Hansen, Torben and Hattersley, Andrew and Laakso, Markku and Pedersen, Oluf and Koivisto, Veikko and Ruetten, Hartmut and Walker, Mark and Pearson, Ewan and Franks, Paul}},
  issn         = {{1432-0428}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1132--1142}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.}},
  url          = {{https://lup.lub.lu.se/search/files/1903029/4731845}},
  doi          = {{10.1007/s00125-014-3216-x}},
  volume       = {{57}},
  year         = {{2014}},
}