Sex-specific differences and similarities of olanzapine and risperidone on avoidance suppression in rats in the conditioned avoidance response test
(2023) In Brain Research 1818.- Abstract
It is well known that antipsychotic drugs (APDs) are more effective in reducing symptoms in women than in men, and that women are more sensitive to the side effects of APDs. Therefore, it is of great importance that sex differences in drug responses are considered already in the early stages of drug development. In this study, we investigated whether sex-specific differences could be observed in response to the commonly prescribed APDs olanzapine and risperidone using the conditioned avoidance response (CAR) test. To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. Whereas there were no significant differences between the female and male... (More)
It is well known that antipsychotic drugs (APDs) are more effective in reducing symptoms in women than in men, and that women are more sensitive to the side effects of APDs. Therefore, it is of great importance that sex differences in drug responses are considered already in the early stages of drug development. In this study, we investigated whether sex-specific differences could be observed in response to the commonly prescribed APDs olanzapine and risperidone using the conditioned avoidance response (CAR) test. To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. Whereas there were no significant differences between the female and male rats in response to either dose of olanzapine administration, an injection of 0.4 mg/kg risperidone significantly suppressed avoidance more in female rats than in male rats. In addition, we found that the estrous cycle of the female rats did not have a significant effect on the avoidance response. In conclusion, we show that there are sex-specific differences as well as similarities between female and male rats in the CAR test and novel APDs should be tested on female and male rats in the future.
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- author
- Titulaer, Joep ; Gottfridsson, Rebecca ; Nordling, Daniel ; Fagerström, Ella ; Eberhard, Jonas LU and Konradsson-Geuken, Åsa LU
- organization
- publishing date
- 2023-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antipsychotic drugs, Conditioned avoidance response test, Olanzapine, Risperidone, Sex differences
- in
- Brain Research
- volume
- 1818
- article number
- 148527
- publisher
- Elsevier
- external identifiers
-
- pmid:37567547
- scopus:85169576858
- ISSN
- 0006-8993
- DOI
- 10.1016/j.brainres.2023.148527
- language
- English
- LU publication?
- yes
- id
- a2655dbf-6953-4511-b125-0ee106a06d54
- date added to LUP
- 2023-10-19 11:43:24
- date last changed
- 2024-04-19 02:34:37
@article{a2655dbf-6953-4511-b125-0ee106a06d54,
abstract = {{<p>It is well known that antipsychotic drugs (APDs) are more effective in reducing symptoms in women than in men, and that women are more sensitive to the side effects of APDs. Therefore, it is of great importance that sex differences in drug responses are considered already in the early stages of drug development. In this study, we investigated whether sex-specific differences could be observed in response to the commonly prescribed APDs olanzapine and risperidone using the conditioned avoidance response (CAR) test. To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. Whereas there were no significant differences between the female and male rats in response to either dose of olanzapine administration, an injection of 0.4 mg/kg risperidone significantly suppressed avoidance more in female rats than in male rats. In addition, we found that the estrous cycle of the female rats did not have a significant effect on the avoidance response. In conclusion, we show that there are sex-specific differences as well as similarities between female and male rats in the CAR test and novel APDs should be tested on female and male rats in the future.</p>}},
author = {{Titulaer, Joep and Gottfridsson, Rebecca and Nordling, Daniel and Fagerström, Ella and Eberhard, Jonas and Konradsson-Geuken, Åsa}},
issn = {{0006-8993}},
keywords = {{Antipsychotic drugs; Conditioned avoidance response test; Olanzapine; Risperidone; Sex differences}},
language = {{eng}},
month = {{11}},
publisher = {{Elsevier}},
series = {{Brain Research}},
title = {{Sex-specific differences and similarities of olanzapine and risperidone on avoidance suppression in rats in the conditioned avoidance response test}},
url = {{http://dx.doi.org/10.1016/j.brainres.2023.148527}},
doi = {{10.1016/j.brainres.2023.148527}},
volume = {{1818}},
year = {{2023}},
}