The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

Antoniou, A. C.; Cunningham, A. P.; Peto, J.; Evans, D. G.; Lalloo, F.; Narod, S. A.; Risch, H. A.; Eyfjord, J. E.; Hopper, J. L.; Southey, M. C.; Olsson, Håkan; Johannsson, O; Borg, Åke; Passini, B.; Radice, P.; Manoukian, S.; Eccles, D. M.; Tang, N.; Olah, E.; Anton-Culver, H.; Warner, E.; Lubinski, J.; Gronwald, J.; Gorski, B.; Tryggvadottir, L.; Syrjakoski, K.; Kallioniemi, O-P; Eerola, H.; Nevanlinna, H.; Pharoah, P. D. P.; Easton, D. F.

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

Mark

Antoniou, A. C. ; Cunningham, A. P. ; Peto, J. ; Evans, D. G. ; Lalloo, F. ; Narod, S. A. ; Risch, H. A. ; Eyfjord, J. E. ; Hopper, J. L. and Southey, M. C. , et al. (2008) In British Journal of Cancer 98(8). p.1457-1466

Abstract: Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth... (More); Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920 - 1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in userfriendly Web-based program(http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home. html). (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1206501

author

Antoniou, A. C. ; Cunningham, A. P. ; Peto, J. ; Evans, D. G. ; Lalloo, F. ; Narod, S. A. ; Risch, H. A. ; Eyfjord, J. E. ; Hopper, J. L. and Southey, M. C. , et al. (More)

Antoniou, A. C. ; Cunningham, A. P. ; Peto, J. ; Evans, D. G. ; Lalloo, F. ; Narod, S. A. ; Risch, H. A. ; Eyfjord, J. E. ; Hopper, J. L. ; Southey, M. C. ; Olsson, Håkan ^LU

; Johannsson, O ; Borg, Åke ^LU ; Passini, B. ; Radice, P. ; Manoukian, S. ; Eccles, D. M. ; Tang, N. ; Olah, E. ; Anton-Culver, H. ; Warner, E. ; Lubinski, J. ; Gronwald, J. ; Gorski, B. ; Tryggvadottir, L. ; Syrjakoski, K. ; Kallioniemi, O-P ; Eerola, H. ; Nevanlinna, H. ; Pharoah, P. D. P. and Easton, D. F. (Less)

organization

Breastcancer-genetics

publishing date

2008

type

Contribution to journal

publication status

published

subject

Cancer and Oncology

keywords

cancer risk model, BRCA1, BRCA2, genetic testing

in

British Journal of Cancer

volume

98

issue

8

pages

1457 - 1466

publisher

Nature Publishing Group

external identifiers

wos:000255006900022
scopus:42149193041

ISSN

1532-1827

DOI

10.1038/sj.bjc.6604305

language

English

LU publication?

yes

id

a292451e-0c4c-4532-9a2c-dd1cdc68b179 (old id 1206501)

date added to LUP

2016-04-01 11:37:59

date last changed

2022-04-12 22:51:41

@article{a292451e-0c4c-4532-9a2c-dd1cdc68b179,
  abstract     = {{Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920 - 1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in userfriendly Web-based program(http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home. html).}},
  author       = {{Antoniou, A. C. and Cunningham, A. P. and Peto, J. and Evans, D. G. and Lalloo, F. and Narod, S. A. and Risch, H. A. and Eyfjord, J. E. and Hopper, J. L. and Southey, M. C. and Olsson, Håkan and Johannsson, O and Borg, Åke and Passini, B. and Radice, P. and Manoukian, S. and Eccles, D. M. and Tang, N. and Olah, E. and Anton-Culver, H. and Warner, E. and Lubinski, J. and Gronwald, J. and Gorski, B. and Tryggvadottir, L. and Syrjakoski, K. and Kallioniemi, O-P and Eerola, H. and Nevanlinna, H. and Pharoah, P. D. P. and Easton, D. F.}},
  issn         = {{1532-1827}},
  keywords     = {{cancer risk model; BRCA1; BRCA2; genetic testing}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1457--1466}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions}},
  url          = {{http://dx.doi.org/10.1038/sj.bjc.6604305}},
  doi          = {{10.1038/sj.bjc.6604305}},
  volume       = {{98}},
  year         = {{2008}},
}

Lund University Publications

LUND UNIVERSITY LIBRARIES

The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions