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The role of PEDF in pancreatic cancer

Ansari, Daniel LU ; Althini, Carl; Ohlsson, Henrik LU ; Bauden, Monika LU and Andersson, Roland LU (2019) In Anticancer research 39(7). p.3311-3315
Abstract

Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review... (More)

Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review the multifunctional role of PEDF in pancreatic cancer and its therapeutic potential.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Angiogenesis, Autophagy, Fibrosis, Inflammation, Metastasis, Pancreatic Cancer, PEDF, Prognosis, Review, Treatment, Tumor growth
in
Anticancer research
volume
39
issue
7
pages
5 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85068265742
ISSN
0250-7005
DOI
10.21873/anticanres.13473
language
English
LU publication?
yes
id
a2a89086-8644-4d4a-a130-a22f39da363e
date added to LUP
2019-07-10 14:17:56
date last changed
2019-08-06 03:24:11
@article{a2a89086-8644-4d4a-a130-a22f39da363e,
  abstract     = {<p>Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review the multifunctional role of PEDF in pancreatic cancer and its therapeutic potential.</p>},
  author       = {Ansari, Daniel and Althini, Carl and Ohlsson, Henrik and Bauden, Monika and Andersson, Roland},
  issn         = {0250-7005},
  keyword      = {Angiogenesis,Autophagy,Fibrosis,Inflammation,Metastasis,Pancreatic Cancer,PEDF,Prognosis,Review,Treatment,Tumor growth},
  language     = {eng},
  number       = {7},
  pages        = {3311--3315},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {The role of PEDF in pancreatic cancer},
  url          = {http://dx.doi.org/10.21873/anticanres.13473},
  volume       = {39},
  year         = {2019},
}