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Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide : Implications in diabetes

Gheibi, Sevda LU ; Samsonov, Alan P. ; Gheibi, Shahsanam ; Vazquez, Alexandra B. and Kashfi, Khosrow (2020) In Biochemical Pharmacology
Abstract

Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the human body and have a key role in many of the physiological activities of the various organ systems. Decreased NO bioavailability and deficiency of H2S are involved in the pathophysiology of type 2 diabetes and its complications. Restoration of NO levels have favorable metabolic effects in diabetes. The role of H2S in pathophysiology of diabetes is however controversial; H2S production is decreased during development of obesity, diabetes, and its complications, suggesting the potential therapeutic effects of H2S. On the other hand, increased H2S levels disturb the pancreatic... (More)

Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the human body and have a key role in many of the physiological activities of the various organ systems. Decreased NO bioavailability and deficiency of H2S are involved in the pathophysiology of type 2 diabetes and its complications. Restoration of NO levels have favorable metabolic effects in diabetes. The role of H2S in pathophysiology of diabetes is however controversial; H2S production is decreased during development of obesity, diabetes, and its complications, suggesting the potential therapeutic effects of H2S. On the other hand, increased H2S levels disturb the pancreatic β-cell function and decrease insulin secretion. In addition, there appear to be important interactions between NO and H2S at the levels of both biosynthesis and signaling pathways, yet clear an insight into this relationship is lacking. H2S potentiates the effects of NO in the cardiovascular system as well as NO release from its storage pools. Likewise, NO increases the activity and the expression of H2S-generating enzymes. Inhibition of NO production leads to elimination/attenuation of the cardioprotective effects of H2S. Regarding the increasing interest in the therapeutic applications of NO or H2S-releasing molecules in a variety of diseases, particularly in the cardiovascular disorders, much is to be learned about their function in glucose/insulin metabolism, especially in diabetes. The aim of this review is to provide a better understanding of the individual and the interactive roles of NO and H2S in carbohydrate metabolism.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Carbohydrate metabolism, Diabetes, Hydrogen sulfide, Nitric oxide
in
Biochemical Pharmacology
article number
113819
publisher
Elsevier
external identifiers
  • pmid:31972170
  • scopus:85078776064
ISSN
0006-2952
DOI
10.1016/j.bcp.2020.113819
language
English
LU publication?
yes
id
a2aeaa8a-9d32-4894-a007-40b6d3e4e4c8
date added to LUP
2020-02-13 15:32:54
date last changed
2020-02-19 05:45:09
@article{a2aeaa8a-9d32-4894-a007-40b6d3e4e4c8,
  abstract     = {<p>Nitric oxide (NO) and hydrogen sulfide (H<sub>2</sub>S) are two gasotransmitters that are produced in the human body and have a key role in many of the physiological activities of the various organ systems. Decreased NO bioavailability and deficiency of H<sub>2</sub>S are involved in the pathophysiology of type 2 diabetes and its complications. Restoration of NO levels have favorable metabolic effects in diabetes. The role of H<sub>2</sub>S in pathophysiology of diabetes is however controversial; H<sub>2</sub>S production is decreased during development of obesity, diabetes, and its complications, suggesting the potential therapeutic effects of H<sub>2</sub>S. On the other hand, increased H<sub>2</sub>S levels disturb the pancreatic β-cell function and decrease insulin secretion. In addition, there appear to be important interactions between NO and H<sub>2</sub>S at the levels of both biosynthesis and signaling pathways, yet clear an insight into this relationship is lacking. H<sub>2</sub>S potentiates the effects of NO in the cardiovascular system as well as NO release from its storage pools. Likewise, NO increases the activity and the expression of H<sub>2</sub>S-generating enzymes. Inhibition of NO production leads to elimination/attenuation of the cardioprotective effects of H<sub>2</sub>S. Regarding the increasing interest in the therapeutic applications of NO or H<sub>2</sub>S-releasing molecules in a variety of diseases, particularly in the cardiovascular disorders, much is to be learned about their function in glucose/insulin metabolism, especially in diabetes. The aim of this review is to provide a better understanding of the individual and the interactive roles of NO and H<sub>2</sub>S in carbohydrate metabolism.</p>},
  author       = {Gheibi, Sevda and Samsonov, Alan P. and Gheibi, Shahsanam and Vazquez, Alexandra B. and Kashfi, Khosrow},
  issn         = {0006-2952},
  language     = {eng},
  month        = {01},
  publisher    = {Elsevier},
  series       = {Biochemical Pharmacology},
  title        = {Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide : Implications in diabetes},
  url          = {http://dx.doi.org/10.1016/j.bcp.2020.113819},
  doi          = {10.1016/j.bcp.2020.113819},
  year         = {2020},
}