Advanced

3D printing of decellularised porcine lung ECM

Tas, Sinem LU ; Bölükbas, Deniz A. LU ; Alsafadi, Hani LU and Wagner, Darcy E. LU (2019) 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence 40. p.962-962
Abstract


Statement of Purpose: Chronic lung diseases are one of the major health problems that cause death and disability. Approximately 65 million people suffer from chronic lung diseases, and the number of patients is predicted to increase worldwide
1
. Lung transplantation is the only available treatment option for patients at end-stage disease. However, there is a chronic shortage of donor organs, resulting in a large unmet clinical need. To tackle this issue, the concept of transplantable bioengineered lungs has been proposed as a solution which... (More)


Statement of Purpose: Chronic lung diseases are one of the major health problems that cause death and disability. Approximately 65 million people suffer from chronic lung diseases, and the number of patients is predicted to increase worldwide
1
. Lung transplantation is the only available treatment option for patients at end-stage disease. However, there is a chronic shortage of donor organs, resulting in a large unmet clinical need. To tackle this issue, the concept of transplantable bioengineered lungs has been proposed as a solution which might help to meet current transplantation needs
2
One of the ways to potentially build complex lung structure is 3D bioprinting, but bioinks which are compatible with 3D printers, support cell growth, and can maintain appropriate mechanical stability are unknown. In this regard, decellularized extracellular matrix (dECM) based materials are considered as a potential novel source of material for bioinks because they have been shown in other contexts to provide a suitable microenvironment for regeneration. However, there has been no investigation of their use in 3D printing of complex shapes. In this study, we evaluated the rheological properties of porcine lungderived dECM solutions and hydrogels to assess their suitability for 3D printing and to determine parameters which can be used to produce stable structures.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Society for Biomaterials Annual Meeting and Exposition 2019 : The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting - The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
volume
40
pages
1 pages
publisher
Swiss Society for Biomaterials
conference name
42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
conference location
Seattle, United States
conference dates
2019-04-03 - 2019-04-06
external identifiers
  • scopus:85065395851
ISBN
9781510883901
language
English
LU publication?
yes
id
a2e9f6e8-b71e-469a-8aa6-56ac5050152b
date added to LUP
2019-05-27 08:39:00
date last changed
2020-04-20 08:32:04
@inproceedings{a2e9f6e8-b71e-469a-8aa6-56ac5050152b,
  abstract     = {<p><br>
                                                         Statement of Purpose: Chronic lung diseases are one of the major health problems that cause death and disability. Approximately 65 million people suffer from chronic lung diseases, and the number of patients is predicted to increase worldwide                             <br>
                            <sup>1</sup><br>
                                                         . Lung transplantation is the only available treatment option for patients at end-stage disease. However, there is a chronic shortage of donor organs, resulting in a large unmet clinical need. To tackle this issue, the concept of transplantable bioengineered lungs has been proposed as a solution which might help to meet current transplantation needs                             <br>
                            <sup>2</sup><br>
                                                          One of the ways to potentially build complex lung structure is 3D bioprinting, but bioinks which are compatible with 3D printers, support cell growth, and can maintain appropriate mechanical stability are unknown. In this regard, decellularized extracellular matrix (dECM) based materials are considered as a potential novel source of material for bioinks because they have been shown in other contexts to provide a suitable microenvironment for regeneration. However, there has been no investigation of their use in 3D printing of complex shapes. In this study, we evaluated the rheological properties of porcine lungderived dECM solutions and hydrogels to assess their suitability for 3D printing and to determine parameters which can be used to produce stable structures.                         <br>
                        </p>},
  author       = {Tas, Sinem and Bölükbas, Deniz A. and Alsafadi, Hani and Wagner, Darcy E.},
  booktitle    = {Society for Biomaterials Annual Meeting and Exposition 2019 : The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting},
  isbn         = {9781510883901},
  language     = {eng},
  pages        = {962--962},
  publisher    = {Swiss Society for Biomaterials},
  title        = {3D printing of decellularised porcine lung ECM},
  volume       = {40},
  year         = {2019},
}