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Release of prolactin as well as adrenocorticotropin after administration of arginine-vasopressin to healthy men

Erfurth, E M LU ; Hedner, P ; Lundin, S and Ekman, R (1996) In Hormone and Metabolic Research 28(11). p.599-602
Abstract

The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in randomized order. Blood samples were taken at 0, 10, 20, 30, 45 and 60 min for analyses of serum or plasma levels of ACTH, prolactin, TSH, GH, FSH, LH and AVP. The hormone responses after AVP or saline were calculated as the area under the curve (AUC) 0-60 min as well as the change in hormone levels from 0 to 10 min to pick up possible short lasting... (More)

The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in randomized order. Blood samples were taken at 0, 10, 20, 30, 45 and 60 min for analyses of serum or plasma levels of ACTH, prolactin, TSH, GH, FSH, LH and AVP. The hormone responses after AVP or saline were calculated as the area under the curve (AUC) 0-60 min as well as the change in hormone levels from 0 to 10 min to pick up possible short lasting effects when there was no significant difference in AUC between AVP and control. As expected the highest plasma concentration of AVP was measured 10 min after the injection of AVP and well comparable to those in other studies where AVP was observed to release ACTH. The AUC:s for both ACTH and prolactin levels were significantly increased after AVP in comparison with saline (p = 0.008 and p = 0.038, respectively). The AUC:s for the other hormones measured were not significantly changed after AVP, but there were small but significant changes in the 0-10 min values for TSH and LH after AVP compared to saline. It is concluded that AVP has the potency to release not only ACTH but also prolactin in healthy men.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adrenocorticotropic Hormone/metabolism, Adult, Arginine Vasopressin/administration & dosage, Follicle Stimulating Hormone/blood, Human Growth Hormone/blood, Humans, Kinetics, Luteinizing Hormone/blood, Male, Prolactin/metabolism, Thyrotropin/blood
in
Hormone and Metabolic Research
volume
28
issue
11
pages
599 - 602
publisher
Georg Thieme Verlag
external identifiers
  • scopus:0029949137
  • pmid:8960901
ISSN
0018-5043
DOI
10.1055/s-2007-979861
language
English
LU publication?
no
id
a2fde5f3-d0e0-4e9e-aafd-4fe8f1e040d0
date added to LUP
2023-11-27 08:49:29
date last changed
2024-01-10 11:52:59
@article{a2fde5f3-d0e0-4e9e-aafd-4fe8f1e040d0,
  abstract     = {{<p>The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in randomized order. Blood samples were taken at 0, 10, 20, 30, 45 and 60 min for analyses of serum or plasma levels of ACTH, prolactin, TSH, GH, FSH, LH and AVP. The hormone responses after AVP or saline were calculated as the area under the curve (AUC) 0-60 min as well as the change in hormone levels from 0 to 10 min to pick up possible short lasting effects when there was no significant difference in AUC between AVP and control. As expected the highest plasma concentration of AVP was measured 10 min after the injection of AVP and well comparable to those in other studies where AVP was observed to release ACTH. The AUC:s for both ACTH and prolactin levels were significantly increased after AVP in comparison with saline (p = 0.008 and p = 0.038, respectively). The AUC:s for the other hormones measured were not significantly changed after AVP, but there were small but significant changes in the 0-10 min values for TSH and LH after AVP compared to saline. It is concluded that AVP has the potency to release not only ACTH but also prolactin in healthy men.</p>}},
  author       = {{Erfurth, E M and Hedner, P and Lundin, S and Ekman, R}},
  issn         = {{0018-5043}},
  keywords     = {{Adrenocorticotropic Hormone/metabolism; Adult; Arginine Vasopressin/administration & dosage; Follicle Stimulating Hormone/blood; Human Growth Hormone/blood; Humans; Kinetics; Luteinizing Hormone/blood; Male; Prolactin/metabolism; Thyrotropin/blood}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{599--602}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Hormone and Metabolic Research}},
  title        = {{Release of prolactin as well as adrenocorticotropin after administration of arginine-vasopressin to healthy men}},
  url          = {{http://dx.doi.org/10.1055/s-2007-979861}},
  doi          = {{10.1055/s-2007-979861}},
  volume       = {{28}},
  year         = {{1996}},
}