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Low BMD is an independent predictor of fracture and early menopause of mortality in post-menopausal women - A 34-year prospective study.

Svejme, Ola LU ; Ahlborg, Henrik LU ; Nilsson, Jan-Åke LU and Karlsson, Magnus LU (2013) In Maturitas 74(4). p.341-345
Abstract
OBJECTIVE: Identify risk factors for fragility fractures and mortality in women aged 48. STUDY DESIGN: Prospective population-based observational study on 390 white north European women aged 48 at study start. At study start, we measured bone mineral density (BMD) by single-photon absorptiometry (SPA) in the distal forearm, anthropometry by standard equipment and registered menopausal status, health and lifestyle factors. Menopause before age 47 was defined as early menopause. Incident fragility fractures and mortality were recorded until the women reached age 82. Potential risk factors for fragility fracture and mortality were evaluated with Cox's proportional hazard regression analysis. Data are presented as risk ratios (RR) with 95%... (More)
OBJECTIVE: Identify risk factors for fragility fractures and mortality in women aged 48. STUDY DESIGN: Prospective population-based observational study on 390 white north European women aged 48 at study start. At study start, we measured bone mineral density (BMD) by single-photon absorptiometry (SPA) in the distal forearm, anthropometry by standard equipment and registered menopausal status, health and lifestyle factors. Menopause before age 47 was defined as early menopause. Incident fragility fractures and mortality were recorded until the women reached age 82. Potential risk factors for fragility fracture and mortality were evaluated with Cox's proportional hazard regression analysis. Data are presented as risk ratios (RR) with 95% confidence intervals in brackets. MAIN OUTCOME MEASURES: Incidence of fragility fractures and mortality. RESULTS: In the univariate analysis, low BMD and early menopause predicted fractures. In the multivariate analysis, only BMD remained as an independent risk factor with a RR of 1.36 (1.15, 1.62) per standard deviation (SD) decrease in baseline BMD. In the univariate analysis, early menopause and smoking predicted mortality, and remained as independent risk factors in the multivariate analysis with RR 1.62 (1.09, 2.39) for early menopause and 2.16 (1.53, 3,06) for smoking. CONCLUSIONS: Low BMD at age 48 is an independent predictor for fragility fractures. The predictive ability of early menopause is at least partially attributed to other associated risk factors. Early menopause and smoking were found in this study to be independent predictors for mortality. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Maturitas
volume
74
issue
4
pages
341 - 345
publisher
Elsevier
external identifiers
  • wos:000317456600007
  • pmid:23374709
  • scopus:84875216780
ISSN
1873-4111
DOI
10.1016/j.maturitas.2013.01.002
language
English
LU publication?
yes
id
a3175569-fb14-4745-b4ac-f5d12c5c2a50 (old id 3560268)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23374709?dopt=Abstract
date added to LUP
2013-03-01 12:49:45
date last changed
2019-05-14 01:10:23
@article{a3175569-fb14-4745-b4ac-f5d12c5c2a50,
  abstract     = {OBJECTIVE: Identify risk factors for fragility fractures and mortality in women aged 48. STUDY DESIGN: Prospective population-based observational study on 390 white north European women aged 48 at study start. At study start, we measured bone mineral density (BMD) by single-photon absorptiometry (SPA) in the distal forearm, anthropometry by standard equipment and registered menopausal status, health and lifestyle factors. Menopause before age 47 was defined as early menopause. Incident fragility fractures and mortality were recorded until the women reached age 82. Potential risk factors for fragility fracture and mortality were evaluated with Cox's proportional hazard regression analysis. Data are presented as risk ratios (RR) with 95% confidence intervals in brackets. MAIN OUTCOME MEASURES: Incidence of fragility fractures and mortality. RESULTS: In the univariate analysis, low BMD and early menopause predicted fractures. In the multivariate analysis, only BMD remained as an independent risk factor with a RR of 1.36 (1.15, 1.62) per standard deviation (SD) decrease in baseline BMD. In the univariate analysis, early menopause and smoking predicted mortality, and remained as independent risk factors in the multivariate analysis with RR 1.62 (1.09, 2.39) for early menopause and 2.16 (1.53, 3,06) for smoking. CONCLUSIONS: Low BMD at age 48 is an independent predictor for fragility fractures. The predictive ability of early menopause is at least partially attributed to other associated risk factors. Early menopause and smoking were found in this study to be independent predictors for mortality.},
  author       = {Svejme, Ola and Ahlborg, Henrik and Nilsson, Jan-Åke and Karlsson, Magnus},
  issn         = {1873-4111},
  language     = {eng},
  number       = {4},
  pages        = {341--345},
  publisher    = {Elsevier},
  series       = {Maturitas},
  title        = {Low BMD is an independent predictor of fracture and early menopause of mortality in post-menopausal women - A 34-year prospective study.},
  url          = {http://dx.doi.org/10.1016/j.maturitas.2013.01.002},
  volume       = {74},
  year         = {2013},
}