Risk of invasive cervical cancer in relation to management of abnormal Pap smear results
(2009) In American Journal of Obstetrics and Gynecology 201(2).- Abstract
- OBJECTIVE: We sought to evaluate the management of women with abnormal cytology in terms of subsequent risk of invasive cervical cancer. STUDY DESIGN: The screening histories of all invasive cervical cancer cases diagnosed in Sweden 1999-2001 and of 5 population-based controls per case were reviewed. In all, 159 patients and 258 control subjects aged < 67 years had an abnormal smear result 0.5-6.5 years prior to cancer diagnosis. The cervical cancer risk was estimated in relation to management by calculating odds ratios. RESULTS: Histologic assessment of low-grade squamous abnormalities strongly reduced the risk compared to repeated cytology (odds ratio, 0.46; 95% confidence interval, 0.24-0.89). Delaying histologic assessment was also... (More)
- OBJECTIVE: We sought to evaluate the management of women with abnormal cytology in terms of subsequent risk of invasive cervical cancer. STUDY DESIGN: The screening histories of all invasive cervical cancer cases diagnosed in Sweden 1999-2001 and of 5 population-based controls per case were reviewed. In all, 159 patients and 258 control subjects aged < 67 years had an abnormal smear result 0.5-6.5 years prior to cancer diagnosis. The cervical cancer risk was estimated in relation to management by calculating odds ratios. RESULTS: Histologic assessment of low-grade squamous abnormalities strongly reduced the risk compared to repeated cytology (odds ratio, 0.46; 95% confidence interval, 0.24-0.89). Delaying histologic assessment was also associated with a higher risk ( odds ratio, 5.65; 95% confidence interval, 1.39-23.05). After high-grade squamous atypia, absence of any cytologic or histologic specimen was a major determinant of cancer risk (odds ratio, 12.52; 95% confidence interval, 1.42-infinitive). CONCLUSION: For adequate protection against invasive cervical cancer, further assessment with histology must be recommended also for women with low-grade squamous abnormalities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1460155
- author
- Silfverdal, Lena ; Kemetli, Levent ; Andrae, Bengt ; Sparen, Par ; Ryd, Walter ; Dillner, Joakim LU ; Strander, Bjorn and Tornberg, Sven
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- population-based case control study, smear results, repeated cytology, management of abnormal Pap, cervical cancer risk, histologic assessment
- in
- American Journal of Obstetrics and Gynecology
- volume
- 201
- issue
- 2
- publisher
- Elsevier
- external identifiers
-
- wos:000268460900022
- scopus:67651087150
- pmid:19560117
- ISSN
- 1097-6868
- DOI
- 10.1016/j.ajog.2009.04.006
- language
- English
- LU publication?
- yes
- id
- a321a67d-1d9e-4332-b3c4-e7d7da390a7d (old id 1460155)
- date added to LUP
- 2016-04-01 12:30:38
- date last changed
- 2020-01-12 09:57:45
@article{a321a67d-1d9e-4332-b3c4-e7d7da390a7d, abstract = {OBJECTIVE: We sought to evaluate the management of women with abnormal cytology in terms of subsequent risk of invasive cervical cancer. STUDY DESIGN: The screening histories of all invasive cervical cancer cases diagnosed in Sweden 1999-2001 and of 5 population-based controls per case were reviewed. In all, 159 patients and 258 control subjects aged < 67 years had an abnormal smear result 0.5-6.5 years prior to cancer diagnosis. The cervical cancer risk was estimated in relation to management by calculating odds ratios. RESULTS: Histologic assessment of low-grade squamous abnormalities strongly reduced the risk compared to repeated cytology (odds ratio, 0.46; 95% confidence interval, 0.24-0.89). Delaying histologic assessment was also associated with a higher risk ( odds ratio, 5.65; 95% confidence interval, 1.39-23.05). After high-grade squamous atypia, absence of any cytologic or histologic specimen was a major determinant of cancer risk (odds ratio, 12.52; 95% confidence interval, 1.42-infinitive). CONCLUSION: For adequate protection against invasive cervical cancer, further assessment with histology must be recommended also for women with low-grade squamous abnormalities.}, author = {Silfverdal, Lena and Kemetli, Levent and Andrae, Bengt and Sparen, Par and Ryd, Walter and Dillner, Joakim and Strander, Bjorn and Tornberg, Sven}, issn = {1097-6868}, language = {eng}, number = {2}, publisher = {Elsevier}, series = {American Journal of Obstetrics and Gynecology}, title = {Risk of invasive cervical cancer in relation to management of abnormal Pap smear results}, url = {http://dx.doi.org/10.1016/j.ajog.2009.04.006}, doi = {10.1016/j.ajog.2009.04.006}, volume = {201}, year = {2009}, }