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Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Törn, Carina LU ; Liu, Xiang ; Onengut-Gumuscu, Suna ; Counts, Kevin M ; Moreno, Jose Leonardo ; Remedios, Cassandra L ; Chen, Wei-Min ; LeFaive, Jonathon ; Butterworth, Martha D and Akolkar, Beena , et al. (2022) In Scientific Reports 12(1). p.4516-4516
Abstract

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than... (More)

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
12
issue
1
pages
4516 - 4516
publisher
Nature Publishing Group
external identifiers
  • pmid:35296692
  • scopus:85126709073
ISSN
2045-2322
DOI
10.1038/s41598-022-08058-7
language
English
LU publication?
yes
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© 2022. The Author(s).
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a32b2773-8459-4349-9a7f-81107562fc27
date added to LUP
2022-03-23 08:33:04
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2024-06-13 13:49:48
@article{a32b2773-8459-4349-9a7f-81107562fc27,
  abstract     = {{<p>The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.</p>}},
  author       = {{Törn, Carina and Liu, Xiang and Onengut-Gumuscu, Suna and Counts, Kevin M and Moreno, Jose Leonardo and Remedios, Cassandra L and Chen, Wei-Min and LeFaive, Jonathon and Butterworth, Martha D and Akolkar, Beena and Krischer, Jeffrey P and Lernmark, Åke and Rewers, Marian and She, Jin-Xiong and Toppari, Jorma and Ziegler, Anette-Gabriele and Ratan, Aakrosh and Smith, Albert V and Hagopian, William A and Rich, Stephen S and Parikh, Hemang M}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{1}},
  pages        = {{4516--4516}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-08058-7}},
  doi          = {{10.1038/s41598-022-08058-7}},
  volume       = {{12}},
  year         = {{2022}},
}