Primary prophylaxis in haemophilia care : Guideline update 2016
Fischer, Kathelijn and Ljung, Rolf LU
(2017)
In Blood Cells, Molecules, and Diseases
67.
p.81-85
- Abstract
This paper reviews the current status on recommendations or guidelines for primary prophylaxis based on recent published papers from organizations or group of experts as well as some original key papers. A rather uniform view exists that prophylaxis should be initiated at an early age before or after no more than a single joint bleed and, if possible, preferably be continued for life. The dose and dose frequency of prophylaxis is dependent on the goal of treatment, bleeding phenotype, compliance, venous access and economic resources in the health care system and should be tailored individually based on clinical outcome and pharmacokinetics. For children, the effectiveness of prophylaxis is more dependent on maintaining minimum trough... (More)
This paper reviews the current status on recommendations or guidelines for primary prophylaxis based on recent published papers from organizations or group of experts as well as some original key papers. A rather uniform view exists that prophylaxis should be initiated at an early age before or after no more than a single joint bleed and, if possible, preferably be continued for life. The dose and dose frequency of prophylaxis is dependent on the goal of treatment, bleeding phenotype, compliance, venous access and economic resources in the health care system and should be tailored individually based on clinical outcome and pharmacokinetics. For children, the effectiveness of prophylaxis is more dependent on maintaining minimum trough levels than in adults. Novel extended half-life products are being introduced, which should not affect the decision on when to start prophylaxis nor the initial dose, but which may be helpful for patients with difficult venous access and which may enable higher trough levels of factor VIII.
(Less)
- author
- Fischer, Kathelijn
and Ljung, Rolf
LU
- organization
- publishing date
- 2017-02-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Factor IX, Factor VIII, Haemophilia A, Haemophilia B, Prophylaxis
- in
- Blood Cells, Molecules, and Diseases
- volume
- 67
- pages
- 81 - 85
- publisher
- Elsevier
- external identifiers
-
- scopus:85014835704
- pmid:28302350
- wos:000414342200014
- ISSN
- 1079-9796
- DOI
- 10.1016/j.bcmd.2017.02.004
- language
- English
- LU publication?
- yes
- id
- a3727dd7-2947-43d5-b95d-612f3514024d
- date added to LUP
- 2017-04-03 10:19:38
- date last changed
- 2024-10-14 03:32:40
@article{a3727dd7-2947-43d5-b95d-612f3514024d,
abstract = {{<p>This paper reviews the current status on recommendations or guidelines for primary prophylaxis based on recent published papers from organizations or group of experts as well as some original key papers. A rather uniform view exists that prophylaxis should be initiated at an early age before or after no more than a single joint bleed and, if possible, preferably be continued for life. The dose and dose frequency of prophylaxis is dependent on the goal of treatment, bleeding phenotype, compliance, venous access and economic resources in the health care system and should be tailored individually based on clinical outcome and pharmacokinetics. For children, the effectiveness of prophylaxis is more dependent on maintaining minimum trough levels than in adults. Novel extended half-life products are being introduced, which should not affect the decision on when to start prophylaxis nor the initial dose, but which may be helpful for patients with difficult venous access and which may enable higher trough levels of factor VIII.</p>}},
author = {{Fischer, Kathelijn and Ljung, Rolf}},
issn = {{1079-9796}},
keywords = {{Factor IX; Factor VIII; Haemophilia A; Haemophilia B; Prophylaxis}},
language = {{eng}},
month = {{02}},
pages = {{81--85}},
publisher = {{Elsevier}},
series = {{Blood Cells, Molecules, and Diseases}},
title = {{Primary prophylaxis in haemophilia care : Guideline update 2016}},
url = {{http://dx.doi.org/10.1016/j.bcmd.2017.02.004}},
doi = {{10.1016/j.bcmd.2017.02.004}},
volume = {{67}},
year = {{2017}},
}