Birth size and cancer prognosis: a systematic review and meta-analysis
Sharma, Shantanu LU ; Kohli, Charu ; Johnson, Linda LU ; Bennet, Louise LU
; Brusselaers, Nele
and Nilsson, Peter M
LU
(2020)
In Journal of Developmental Origins of Health and Disease
11(4).
p.309-316
- Abstract
- There is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth parameters and the cancer mortality risk. Therefore, we aimed to review and analyse the available data on the association linking birth weight and birth length with cancer mortality. Eleven studies were identified, published until April 2019. A significant association between birth weight and the prognosis of cancer (overall) was found (relative risk,... (More)
- There is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth parameters and the cancer mortality risk. Therefore, we aimed to review and analyse the available data on the association linking birth weight and birth length with cancer mortality. Eleven studies were identified, published until April 2019. A significant association between birth weight and the prognosis of cancer (overall) was found (relative risk, RR 1.06, 95% confidence interval, CI: 1.01, 1.11), with low heterogeneity (I2 = 27.7%). In addition, higher birth weight was associated with poorer prognosis of prostate cancer (RR 1.21, 95% CI: 1.02, 1.44). However, the association of birth weight with breast cancer mortality risk in women was not significant (RR 1.16, 95% CI: 0.93, 1.44), which might be due to high statistical heterogeneity (I2 = 67.9%). Birth length was not associated with cancer mortality risk (RR 1.0, 95% CI: 0.90–1.11). It might be inferred that birth parameters are not associated with cancer mortality as strongly as with the risk of developing cancer. Also, the association between birth parameters and cancer mortality risk is not uniform and varies according to its subtypes, and study characteristics/design. This highlights the need for further prospective studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a3745e26-a42e-4d6a-83c2-db2980dac1dd
- author
- Sharma, Shantanu
LU
; Kohli, Charu
; Johnson, Linda
LU
; Bennet, Louise
LU
; Brusselaers, Nele
and Nilsson, Peter M
LU
- organization
- publishing date
- 2020-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Developmental Origins of Health and Disease
- volume
- 11
- issue
- 4
- pages
- 8 pages
- publisher
- Cambridge University Press
- external identifiers
-
- pmid:31647397
- scopus:85074340379
- ISSN
- 2040-1752
- DOI
- 10.1017/S2040174419000631
- language
- English
- LU publication?
- yes
- id
- a3745e26-a42e-4d6a-83c2-db2980dac1dd
- date added to LUP
- 2020-02-20 12:12:37
- date last changed
- 2024-02-16 10:59:52
@article{a3745e26-a42e-4d6a-83c2-db2980dac1dd,
abstract = {{There is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth parameters and the cancer mortality risk. Therefore, we aimed to review and analyse the available data on the association linking birth weight and birth length with cancer mortality. Eleven studies were identified, published until April 2019. A significant association between birth weight and the prognosis of cancer (overall) was found (relative risk, RR 1.06, 95% confidence interval, CI: 1.01, 1.11), with low heterogeneity (I2 = 27.7%). In addition, higher birth weight was associated with poorer prognosis of prostate cancer (RR 1.21, 95% CI: 1.02, 1.44). However, the association of birth weight with breast cancer mortality risk in women was not significant (RR 1.16, 95% CI: 0.93, 1.44), which might be due to high statistical heterogeneity (I2 = 67.9%). Birth length was not associated with cancer mortality risk (RR 1.0, 95% CI: 0.90–1.11). It might be inferred that birth parameters are not associated with cancer mortality as strongly as with the risk of developing cancer. Also, the association between birth parameters and cancer mortality risk is not uniform and varies according to its subtypes, and study characteristics/design. This highlights the need for further prospective studies.}},
author = {{Sharma, Shantanu and Kohli, Charu and Johnson, Linda and Bennet, Louise and Brusselaers, Nele and Nilsson, Peter M}},
issn = {{2040-1752}},
language = {{eng}},
number = {{4}},
pages = {{309--316}},
publisher = {{Cambridge University Press}},
series = {{Journal of Developmental Origins of Health and Disease}},
title = {{Birth size and cancer prognosis: a systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.1017/S2040174419000631}},
doi = {{10.1017/S2040174419000631}},
volume = {{11}},
year = {{2020}},
}