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Parental cancer as a risk factor for brain tumors (Sweden)

Hemminki, K LU ; Li, Xinjun LU and Collins, V P (2001) In Cancer Causes and Control 12(3). p.9-195
Abstract

OBJECTIVE: We used the nationwide Swedish Family-Cancer Database to analyze the risk for adult (15-61 years) brain tumors in offspring through parental cancer probands. Additionally, cancer risks were assessed among siblings of brain tumor probands.

METHODS: In offspring and parents, respectively, 5,425 and 20,938 cases of brain tumors were diagnosed between the years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for brain tumors.

RESULTS: Of brain tumor patients, 2.1% had a parent with nervous system cancer; SIRs were 1.7, 2.4, and 2.5 for all brain tumors, astrocytomas, and meningiomas, respectively. Parental endometrial cancer and melanoma were associated with... (More)

OBJECTIVE: We used the nationwide Swedish Family-Cancer Database to analyze the risk for adult (15-61 years) brain tumors in offspring through parental cancer probands. Additionally, cancer risks were assessed among siblings of brain tumor probands.

METHODS: In offspring and parents, respectively, 5,425 and 20,938 cases of brain tumors were diagnosed between the years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for brain tumors.

RESULTS: Of brain tumor patients, 2.1% had a parent with nervous system cancer; SIRs were 1.7, 2.4, and 2.5 for all brain tumors, astrocytomas, and meningiomas, respectively. Parental endometrial cancer and melanoma were associated with offspring astrocytoma, and parental breast and thyroid cancers with offspring ependymoma and neurinoma, respectively. SIR for sibling nervous system tumors from brain tumor probands was not increased overall but was 2.5 in those diagnosed at ages 15-34 years.

CONCLUSION: These data show a familial risk for brain tumors among adults.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Age of Onset, Brain Neoplasms/diagnosis, Databases, Factual, Family Health, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Middle Aged, Nuclear Family, Parents, Pedigree, Prospective Studies, Registries, Risk Assessment, Risk Factors, Sweden/epidemiology
in
Cancer Causes and Control
volume
12
issue
3
pages
5 pages
publisher
Springer
external identifiers
  • scopus:0034987667
ISSN
0957-5243
language
English
LU publication?
no
id
a3e0dd54-de28-4955-975d-a731a71260fc
alternative location
https://www.jstor.org/stable/3553672
date added to LUP
2019-01-30 12:16:14
date last changed
2019-02-21 11:42:13
@article{a3e0dd54-de28-4955-975d-a731a71260fc,
  abstract     = {<p>OBJECTIVE: We used the nationwide Swedish Family-Cancer Database to analyze the risk for adult (15-61 years) brain tumors in offspring through parental cancer probands. Additionally, cancer risks were assessed among siblings of brain tumor probands.</p><p>METHODS: In offspring and parents, respectively, 5,425 and 20,938 cases of brain tumors were diagnosed between the years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for brain tumors.</p><p>RESULTS: Of brain tumor patients, 2.1% had a parent with nervous system cancer; SIRs were 1.7, 2.4, and 2.5 for all brain tumors, astrocytomas, and meningiomas, respectively. Parental endometrial cancer and melanoma were associated with offspring astrocytoma, and parental breast and thyroid cancers with offspring ependymoma and neurinoma, respectively. SIR for sibling nervous system tumors from brain tumor probands was not increased overall but was 2.5 in those diagnosed at ages 15-34 years.</p><p>CONCLUSION: These data show a familial risk for brain tumors among adults.</p>},
  author       = {Hemminki, K and Li, Xinjun and Collins, V P},
  issn         = {0957-5243},
  keyword      = {Adolescent,Adult,Age of Onset,Brain Neoplasms/diagnosis,Databases, Factual,Family Health,Female,Genetic Predisposition to Disease,Humans,Incidence,Male,Middle Aged,Nuclear Family,Parents,Pedigree,Prospective Studies,Registries,Risk Assessment,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {9--195},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Parental cancer as a risk factor for brain tumors (Sweden)},
  volume       = {12},
  year         = {2001},
}