Advanced

Haemophilus Protein F Orthologs of Pathogens Infecting the Airways : Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells

Su, Yu Ching LU ; Halang, Petra LU ; Fleury, Christophe LU ; Jalalvand, Farshid LU ; Mörgelin, Matthias LU and Riesbeck, Kristian LU (2017) In The Journal of infectious diseases 216(10). p.1303-1307
Abstract

Haemophilus influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously expressed in the respiratory tract. Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that occasionally colonize and infect the human airways. Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin. Interestingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains, and also attached to laminin expressed on respiratory epithelial cells. Laminin is thus a highly important target for PF orthologs of the bacterial species examined.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adherence, airway pathogen, epithelial cells, heparin-binding domain, laminin, LG globular domain
in
The Journal of infectious diseases
volume
216
issue
10
pages
5 pages
publisher
Oxford University Press
external identifiers
  • scopus:85039871727
ISSN
1537-6613
DOI
10.1093/infdis/jix467
language
English
LU publication?
yes
id
a3e22f68-17ea-49de-abf4-c5d739fcb975
date added to LUP
2018-01-22 16:32:26
date last changed
2019-07-16 03:41:56
@article{a3e22f68-17ea-49de-abf4-c5d739fcb975,
  abstract     = {<p>Haemophilus influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously expressed in the respiratory tract. Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that occasionally colonize and infect the human airways. Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin. Interestingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains, and also attached to laminin expressed on respiratory epithelial cells. Laminin is thus a highly important target for PF orthologs of the bacterial species examined.</p>},
  author       = {Su, Yu Ching and Halang, Petra and Fleury, Christophe and Jalalvand, Farshid and Mörgelin, Matthias and Riesbeck, Kristian},
  issn         = {1537-6613},
  keyword      = {Adherence,airway pathogen,epithelial cells,heparin-binding domain,laminin,LG globular domain},
  language     = {eng},
  number       = {10},
  pages        = {1303--1307},
  publisher    = {Oxford University Press},
  series       = {The Journal of infectious diseases},
  title        = {Haemophilus Protein F Orthologs of Pathogens Infecting the Airways : Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells},
  url          = {http://dx.doi.org/10.1093/infdis/jix467},
  volume       = {216},
  year         = {2017},
}