Haemophilus Protein F Orthologs of Pathogens Infecting the Airways : Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells
(2017) In The Journal of infectious diseases 216(10). p.1303-1307- Abstract
Haemophilus influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously expressed in the respiratory tract. Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that occasionally colonize and infect the human airways. Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin. Interestingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains, and also attached to laminin expressed on respiratory epithelial cells. Laminin is thus a highly important target for PF orthologs of the bacterial species examined.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a3e22f68-17ea-49de-abf4-c5d739fcb975
- author
- Su, Yu Ching
LU
; Halang, Petra
LU
; Fleury, Christophe
LU
; Jalalvand, Farshid
LU
; Mörgelin, Matthias
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adherence, airway pathogen, epithelial cells, heparin-binding domain, laminin, LG globular domain
- in
- The Journal of infectious diseases
- volume
- 216
- issue
- 10
- pages
- 5 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85039871727
- pmid:28968674
- ISSN
- 1537-6613
- DOI
- 10.1093/infdis/jix467
- language
- English
- LU publication?
- yes
- id
- a3e22f68-17ea-49de-abf4-c5d739fcb975
- date added to LUP
- 2018-01-22 16:32:26
- date last changed
- 2025-01-08 04:04:47
@article{a3e22f68-17ea-49de-abf4-c5d739fcb975, abstract = {{<p>Haemophilus influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously expressed in the respiratory tract. Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that occasionally colonize and infect the human airways. Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin. Interestingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains, and also attached to laminin expressed on respiratory epithelial cells. Laminin is thus a highly important target for PF orthologs of the bacterial species examined.</p>}}, author = {{Su, Yu Ching and Halang, Petra and Fleury, Christophe and Jalalvand, Farshid and Mörgelin, Matthias and Riesbeck, Kristian}}, issn = {{1537-6613}}, keywords = {{Adherence; airway pathogen; epithelial cells; heparin-binding domain; laminin; LG globular domain}}, language = {{eng}}, number = {{10}}, pages = {{1303--1307}}, publisher = {{Oxford University Press}}, series = {{The Journal of infectious diseases}}, title = {{Haemophilus Protein F Orthologs of Pathogens Infecting the Airways : Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells}}, url = {{http://dx.doi.org/10.1093/infdis/jix467}}, doi = {{10.1093/infdis/jix467}}, volume = {{216}}, year = {{2017}}, }