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GFR-gränsen har sänkts för metformin vid typ 2-diabetes : Nya rekommendationer vid nedsatt njurfunktion och undersökning med jodkontrastmedel

Sterner, Gunnar LU and Frid, Anders LU (2018) In Lakartidningen 115(15).
Abstract

Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.

Abstract (Swedish)
Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
115
issue
15
pages
1 pages
publisher
Swedish Medical Association
external identifiers
  • scopus:85058874352
  • scopus:85045476863
ISSN
0023-7205
language
Swedish
LU publication?
no
id
a4210e89-f9be-49ec-ad11-8e7a0fcc97e9
alternative location
http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2018/04/GFR-gransen-har-sankts-for-metformin-vid-typ-2-diabetes/
date added to LUP
2018-04-24 15:58:58
date last changed
2019-02-20 11:15:14
@article{a4210e89-f9be-49ec-ad11-8e7a0fcc97e9,
  abstract     = {<p>Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min. Determination of metformin levels in serum is useful to guide therapeutic dose when GFR is low but also to confirm that lactic acidosis is caused by metformin.</p>},
  author       = {Sterner, Gunnar and Frid, Anders},
  issn         = {0023-7205},
  language     = {swe},
  month        = {01},
  number       = {15},
  publisher    = {Swedish Medical Association},
  series       = {Lakartidningen},
  title        = {GFR-gränsen har sänkts för metformin vid typ 2-diabetes : Nya rekommendationer vid nedsatt njurfunktion och undersökning med jodkontrastmedel},
  url          = {http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2018/04/GFR-gransen-har-sankts-for-metformin-vid-typ-2-diabetes/},
  volume       = {115},
  year         = {2018},
}