Life is pain : Fibromyalgia as a nexus of multiple liability distributions
(2023) In American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 192(7-8). p.171-182- Abstract
Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnosis, treatment, and clinical heterogeneity. To clarify this etiology, healthcare-based data are leveraged to assess the influences on fibromyalgia in several domains. Prevalence is less than 1% of females in our population register data, and about 1/10th that in males. Fibromyalgia often presents with co-occurring conditions including back pain, rheumatoid arthritis, and anxiety. More comorbidities are identified with hospital-associated biobank data, falling into three broad categories of pain-related, autoimmune, and psychiatric disorders. Selecting representative phenotypes with published genome-wide association results for polygenic... (More)
Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnosis, treatment, and clinical heterogeneity. To clarify this etiology, healthcare-based data are leveraged to assess the influences on fibromyalgia in several domains. Prevalence is less than 1% of females in our population register data, and about 1/10th that in males. Fibromyalgia often presents with co-occurring conditions including back pain, rheumatoid arthritis, and anxiety. More comorbidities are identified with hospital-associated biobank data, falling into three broad categories of pain-related, autoimmune, and psychiatric disorders. Selecting representative phenotypes with published genome-wide association results for polygenic scoring, we confirm genetic predispositions to psychiatric, pain sensitivity, and autoimmune conditions show associations with fibromyalgia, although these may differ by ancestry group. We conduct a genome-wide association analysis of fibromyalgia in biobank samples, which did not result in any genome-wide significant loci; further studies with increased sample size are necessary to identify specific genetic effects on fibromyalgia. Overall, fibromyalgia appears to have strong clinical and likely genetic links to several disease categories, and could usefully be understood as a composite manifestation of these etiological sources.
(Less)
- author
- organization
- publishing date
- 2023-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- epidemiology, etiology, fibromyalgia, genetics, phenome
- in
- American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
- volume
- 192
- issue
- 7-8
- pages
- 12 pages
- publisher
- International Society of Psychiatric Genetics
- external identifiers
-
- pmid:37334860
- scopus:85162013728
- ISSN
- 1552-4841
- DOI
- 10.1002/ajmg.b.32949
- language
- English
- LU publication?
- yes
- id
- a4893674-ee59-490d-91c3-2a1a05240837
- date added to LUP
- 2023-10-23 13:15:22
- date last changed
- 2024-04-19 02:44:12
@article{a4893674-ee59-490d-91c3-2a1a05240837,
abstract = {{<p>Fibromyalgia is a complex disease of unclear etiology that is complicated by difficulties in diagnosis, treatment, and clinical heterogeneity. To clarify this etiology, healthcare-based data are leveraged to assess the influences on fibromyalgia in several domains. Prevalence is less than 1% of females in our population register data, and about 1/10th that in males. Fibromyalgia often presents with co-occurring conditions including back pain, rheumatoid arthritis, and anxiety. More comorbidities are identified with hospital-associated biobank data, falling into three broad categories of pain-related, autoimmune, and psychiatric disorders. Selecting representative phenotypes with published genome-wide association results for polygenic scoring, we confirm genetic predispositions to psychiatric, pain sensitivity, and autoimmune conditions show associations with fibromyalgia, although these may differ by ancestry group. We conduct a genome-wide association analysis of fibromyalgia in biobank samples, which did not result in any genome-wide significant loci; further studies with increased sample size are necessary to identify specific genetic effects on fibromyalgia. Overall, fibromyalgia appears to have strong clinical and likely genetic links to several disease categories, and could usefully be understood as a composite manifestation of these etiological sources.</p>}},
author = {{Moscati, Arden and Faucon, Annika B. and Arnaiz-Yépez, Cayetana and Lönn, Sara Larsson and Sundquist, Jan and Sundquist, Kristina and Belbin, Gillian M. and Nadkarni, Girish and Cho, Judy H. and Loos, Ruth J.F. and Davis, Lea K. and Kendler, Kenneth S.}},
issn = {{1552-4841}},
keywords = {{epidemiology; etiology; fibromyalgia; genetics; phenome}},
language = {{eng}},
number = {{7-8}},
pages = {{171--182}},
publisher = {{International Society of Psychiatric Genetics}},
series = {{American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics}},
title = {{Life is pain : Fibromyalgia as a nexus of multiple liability distributions}},
url = {{http://dx.doi.org/10.1002/ajmg.b.32949}},
doi = {{10.1002/ajmg.b.32949}},
volume = {{192}},
year = {{2023}},
}