Effects on Serum Protein Levels From One Bout of High Intensity Interval Training in Individuals With Axial Spondyloarthritis and Controls
Andersson, Åsa ; Olsson, M Charlotte ; Torell, Anna LU ; Mogard, Elisabeth LU
and Haglund, Emma
LU
(2025)
In Immunity, Inflammation and Disease
13(12).
- Abstract
BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. In the herein presented pilot study, the aim was to investigate if serum levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT in individuals with axSpA and healthy controls (HC).
METHODS: Ten... (More)
BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. In the herein presented pilot study, the aim was to investigate if serum levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT in individuals with axSpA and healthy controls (HC).
METHODS: Ten participants with axSpA (medication: 6 NSAIDs, 3 biologics, 1 no-treatment) and 11 age- and sex-matched HC performed a single HIIT bout on a cycle ergometer: 4 × 4 min intervals with 3 min active rest in between. Blood samples were taken before and 1 h after the HIIT bout. Serum proteins (IL-6, IL-17, IL-18, TNF-α, CXCL-10, VEGF-A, BDNF, DKK-1, osteoprotegerin, osteocalcin, osteopontin, BMP-7, CRP) were analyzed with a Luminex system or ELISA. A two-way ANOVA was used for comparisons.
RESULTS: A main effect from baseline to 1 h post HIIT showed that both groups had a significant increase in serum levels of IL-6. VEGF-A was significantly lower in the axSpA group but was not affected by the HIIT bout. BMP-7 increased in both groups after the HIIT. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT.
CONCLUSIONS: One acute bout of HIIT significantly increases the serum concentrations of IL-6 and BMP-7 after 1 h in both individuals with axSpA and HC, whereas serum levels of other proteins investigated are not changed.
(Less)
- author
- Andersson, Åsa
; Olsson, M Charlotte
; Torell, Anna
LU
; Mogard, Elisabeth
LU
and Haglund, Emma
LU
- organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Male, Female, Adult, High-Intensity Interval Training, Cytokines/blood, Axial Spondyloarthritis/blood, Pilot Projects, Blood Proteins/metabolism, Biomarkers/blood, Middle Aged, Case-Control Studies
- in
- Immunity, Inflammation and Disease
- volume
- 13
- issue
- 12
- article number
- e70305
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:41392020
- ISSN
- 2050-4527
- DOI
- 10.1002/iid3.70305
- language
- English
- LU publication?
- yes
- additional info
- © 2025 The Author(s). Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
- id
- a4937c75-de8e-45f6-a4a8-a49a643a140e
- date added to LUP
- 2025-12-15 08:49:31
- date last changed
- 2025-12-15 08:49:31
@article{a4937c75-de8e-45f6-a4a8-a49a643a140e,
abstract = {{<p>BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on disease activity and the level of inflammation in axSpA has been less studied. In the herein presented pilot study, the aim was to investigate if serum levels of inflammatory cytokines, myokines, and protein markers for bone metabolism are acutely affected by one bout of HIIT in individuals with axSpA and healthy controls (HC).</p><p>METHODS: Ten participants with axSpA (medication: 6 NSAIDs, 3 biologics, 1 no-treatment) and 11 age- and sex-matched HC performed a single HIIT bout on a cycle ergometer: 4 × 4 min intervals with 3 min active rest in between. Blood samples were taken before and 1 h after the HIIT bout. Serum proteins (IL-6, IL-17, IL-18, TNF-α, CXCL-10, VEGF-A, BDNF, DKK-1, osteoprotegerin, osteocalcin, osteopontin, BMP-7, CRP) were analyzed with a Luminex system or ELISA. A two-way ANOVA was used for comparisons.</p><p>RESULTS: A main effect from baseline to 1 h post HIIT showed that both groups had a significant increase in serum levels of IL-6. VEGF-A was significantly lower in the axSpA group but was not affected by the HIIT bout. BMP-7 increased in both groups after the HIIT. For the other proteins analyzed, there were no significant differences in serum concentrations between individuals with axSpA and HC, or within the two groups before and after one bout of HIIT.</p><p>CONCLUSIONS: One acute bout of HIIT significantly increases the serum concentrations of IL-6 and BMP-7 after 1 h in both individuals with axSpA and HC, whereas serum levels of other proteins investigated are not changed.</p>}},
author = {{Andersson, Åsa and Olsson, M Charlotte and Torell, Anna and Mogard, Elisabeth and Haglund, Emma}},
issn = {{2050-4527}},
keywords = {{Humans; Male; Female; Adult; High-Intensity Interval Training; Cytokines/blood; Axial Spondyloarthritis/blood; Pilot Projects; Blood Proteins/metabolism; Biomarkers/blood; Middle Aged; Case-Control Studies}},
language = {{eng}},
number = {{12}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Immunity, Inflammation and Disease}},
title = {{Effects on Serum Protein Levels From One Bout of High Intensity Interval Training in Individuals With Axial Spondyloarthritis and Controls}},
url = {{http://dx.doi.org/10.1002/iid3.70305}},
doi = {{10.1002/iid3.70305}},
volume = {{13}},
year = {{2025}},
}