CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions
(2004) In Arteriosclerosis, Thrombosis and Vascular Biology 24(4). p.750-750- Abstract
- OBJECTIVE: Atherosclerosis is an inflammatory disease. Several chemokines are important for monocyte/macrophage and T-cell recruitment to the lesion. CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR-PSOX, which mediates uptake of oxidized low-density lipoprotein. We investigated whether CXCL16 expression is controlled by interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions. METHODS AND RESULTS: CXCL16 and CXCR6 expression was identified by polymerase chain reaction and histochemistry in atherosclerotic lesions from humans and... (More)
- OBJECTIVE: Atherosclerosis is an inflammatory disease. Several chemokines are important for monocyte/macrophage and T-cell recruitment to the lesion. CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR-PSOX, which mediates uptake of oxidized low-density lipoprotein. We investigated whether CXCL16 expression is controlled by interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions. METHODS AND RESULTS: CXCL16 and CXCR6 expression was identified by polymerase chain reaction and histochemistry in atherosclerotic lesions from humans and apolipoprotein-E-deficient mice. In vitro IFN-gamma induced CXCL16 in human monocytic THP-1 cells and primary human monocytes, which led to increased uptake of oxidized low-density lipoprotein in THP-1 cells, which could be blocked by peptide antibodies against CXCL16. In vivo IFN-gamma induced CXCL16 expression in murine atherosclerotic lesions. CONCLUSIONS: We demonstrate a novel role of IFN-gamma in foam cell formation through upregulation of CXCL16/SR-PSOX. CXCR6 expression in the plaque confirms the presence of cells able to respond to CXCL16. Therefore, this chemokine/scavenger receptor could serve as a molecular link between lipid metabolism and immune activity in the atherosclerotic lesion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129700
- author
- Wuttge, Dirk LU ; Zhou, Xinghua ; Sheikine, Yuri ; Wagsater, Dick ; Stemme, Veronika ; Hedin, Ulf ; Stemme, Sten ; Hansson, Goran K and Sirsjo, Allan
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atherosclerosis, chemokines, oxidized low-density lipoprotein, interferon-{gamma), scavenger receptors
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 24
- issue
- 4
- pages
- 750 - 750
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:14988089
- scopus:11144357326
- pmid:14988089
- ISSN
- 1524-4636
- DOI
- 10.1161/01.ATV.0000124102.11472.36
- language
- English
- LU publication?
- no
- id
- a4a89a77-6245-40ad-adfc-12ba8e92c5b8 (old id 1129700)
- date added to LUP
- 2016-04-01 12:24:08
- date last changed
- 2022-01-27 03:16:23
@article{a4a89a77-6245-40ad-adfc-12ba8e92c5b8,
abstract = {{OBJECTIVE: Atherosclerosis is an inflammatory disease. Several chemokines are important for monocyte/macrophage and T-cell recruitment to the lesion. CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells. It is identical to scavenger receptor SR-PSOX, which mediates uptake of oxidized low-density lipoprotein. We investigated whether CXCL16 expression is controlled by interferon-gamma (IFN-gamma)-cytokine abundant in atherosclerotic lesions. METHODS AND RESULTS: CXCL16 and CXCR6 expression was identified by polymerase chain reaction and histochemistry in atherosclerotic lesions from humans and apolipoprotein-E-deficient mice. In vitro IFN-gamma induced CXCL16 in human monocytic THP-1 cells and primary human monocytes, which led to increased uptake of oxidized low-density lipoprotein in THP-1 cells, which could be blocked by peptide antibodies against CXCL16. In vivo IFN-gamma induced CXCL16 expression in murine atherosclerotic lesions. CONCLUSIONS: We demonstrate a novel role of IFN-gamma in foam cell formation through upregulation of CXCL16/SR-PSOX. CXCR6 expression in the plaque confirms the presence of cells able to respond to CXCL16. Therefore, this chemokine/scavenger receptor could serve as a molecular link between lipid metabolism and immune activity in the atherosclerotic lesion.}},
author = {{Wuttge, Dirk and Zhou, Xinghua and Sheikine, Yuri and Wagsater, Dick and Stemme, Veronika and Hedin, Ulf and Stemme, Sten and Hansson, Goran K and Sirsjo, Allan}},
issn = {{1524-4636}},
keywords = {{atherosclerosis; chemokines; oxidized low-density lipoprotein; interferon-{gamma); scavenger receptors}},
language = {{eng}},
number = {{4}},
pages = {{750--750}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions}},
url = {{http://dx.doi.org/10.1161/01.ATV.0000124102.11472.36}},
doi = {{10.1161/01.ATV.0000124102.11472.36}},
volume = {{24}},
year = {{2004}},
}