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Breast Cancer in Systemic Lupus Erythematosus

Cloutier, B. Tessier; Clarke, A. E.; Ramsey-Goldman, R.; Wang, Y.; Foulkes, W.; Gordon, C.; Hansen, J. E.; Yelin, E.; Urowitz, M. B. and Gladman, D., et al. (2013) In Oncology 85(2). p.117-121
Abstract
Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular... (More)
Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (Cl) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% Cl 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status. Copyright (C) 2013 S. Karger AG, Basel (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, Systemic lupus erythematosus, Histopathology, Epidemiology
in
Oncology
volume
85
issue
2
pages
117 - 121
publisher
Karger
external identifiers
  • wos:000323873300007
  • scopus:84880396935
ISSN
1423-0232
DOI
10.1159/000353138
language
English
LU publication?
yes
id
a4c86254-2f1d-4d9e-a709-747c0c1f1bd6 (old id 4062612)
date added to LUP
2014-03-03 08:12:27
date last changed
2019-03-27 01:04:07
@article{a4c86254-2f1d-4d9e-a709-747c0c1f1bd6,
  abstract     = {Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (Cl) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% Cl 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status. Copyright (C) 2013 S. Karger AG, Basel},
  author       = {Cloutier, B. Tessier and Clarke, A. E. and Ramsey-Goldman, R. and Wang, Y. and Foulkes, W. and Gordon, C. and Hansen, J. E. and Yelin, E. and Urowitz, M. B. and Gladman, D. and Fortin, P. R. and Wallace, D. J. and Petri, M. and Manzi, S. and Ginzler, E. M. and Labrecque, J. and Edworthy, S. and Dooley, M. A. and Senecal, J. L. and Peschken, C. A. and Bae, S. C. and Isenberg, D. and Rahman, A. and Ruiz-Irastorza, G. and Hanly, J. G. and Jacobsen, S. and Nived, Ola and Witte, T. and Criswell, L. A. and Barr, S. G. and Dreyer, L. and Sturfelt, Gunnar and Bernatsky, S.},
  issn         = {1423-0232},
  keyword      = {Breast cancer,Systemic lupus erythematosus,Histopathology,Epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {117--121},
  publisher    = {Karger},
  series       = {Oncology},
  title        = {Breast Cancer in Systemic Lupus Erythematosus},
  url          = {http://dx.doi.org/10.1159/000353138},
  volume       = {85},
  year         = {2013},
}