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L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer

Norrsell, Ragnar ; Bauden, Monika LU orcid ; Andersson, Roland LU and Ansari, Daniel LU (2024) In Cancer Control 31.
Abstract

Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and confers a poor prognosis. Here we discuss the prospects of utilizing LAT1 as a novel target for pancreatic cancer therapy.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
LAT1, pancreatic cancer, prognosis, therapy
in
Cancer Control
volume
31
publisher
SAGE Publications
external identifiers
  • scopus:85191689387
  • pmid:38683590
ISSN
1073-2748
DOI
10.1177/10732748241251583
language
English
LU publication?
yes
id
a5292461-df82-4c90-9820-d4307e299b2a
date added to LUP
2024-05-16 12:02:56
date last changed
2024-06-13 14:47:43
@misc{a5292461-df82-4c90-9820-d4307e299b2a,
  abstract     = {{<p>Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and confers a poor prognosis. Here we discuss the prospects of utilizing LAT1 as a novel target for pancreatic cancer therapy.</p>}},
  author       = {{Norrsell, Ragnar and Bauden, Monika and Andersson, Roland and Ansari, Daniel}},
  issn         = {{1073-2748}},
  keywords     = {{LAT1; pancreatic cancer; prognosis; therapy}},
  language     = {{eng}},
  publisher    = {{SAGE Publications}},
  series       = {{Cancer Control}},
  title        = {{L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer}},
  url          = {{http://dx.doi.org/10.1177/10732748241251583}},
  doi          = {{10.1177/10732748241251583}},
  volume       = {{31}},
  year         = {{2024}},
}