L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer
(2024) In Cancer Control 31.- Abstract
Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and confers a poor prognosis. Here we discuss the prospects of utilizing LAT1 as a novel target for pancreatic cancer therapy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a5292461-df82-4c90-9820-d4307e299b2a
- author
- Norrsell, Ragnar
; Bauden, Monika
LU
; Andersson, Roland LU and Ansari, Daniel LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- LAT1, pancreatic cancer, prognosis, therapy
- in
- Cancer Control
- volume
- 31
- publisher
- SAGE Publications
- external identifiers
-
- scopus:85191689387
- pmid:38683590
- ISSN
- 1073-2748
- DOI
- 10.1177/10732748241251583
- language
- English
- LU publication?
- yes
- id
- a5292461-df82-4c90-9820-d4307e299b2a
- date added to LUP
- 2024-05-16 12:02:56
- date last changed
- 2024-06-13 14:47:43
@misc{a5292461-df82-4c90-9820-d4307e299b2a, abstract = {{<p>Metabolic rewiring is a key feature of cancer cells to support the demands of growth and proliferation. The metabolism of amino acids is altered in many cancers, including pancreatic cancer. The cellular uptake of amino acids is regulated by amino acid transporters, such as L-type amino acid transporter 1 (LAT1). Accumulating evidence suggests that LAT1 is overexpressed in pancreatic cancer and confers a poor prognosis. Here we discuss the prospects of utilizing LAT1 as a novel target for pancreatic cancer therapy.</p>}}, author = {{Norrsell, Ragnar and Bauden, Monika and Andersson, Roland and Ansari, Daniel}}, issn = {{1073-2748}}, keywords = {{LAT1; pancreatic cancer; prognosis; therapy}}, language = {{eng}}, publisher = {{SAGE Publications}}, series = {{Cancer Control}}, title = {{L-type Amino Acid Transporter 1 as a Therapeutic Target in Pancreatic Cancer}}, url = {{http://dx.doi.org/10.1177/10732748241251583}}, doi = {{10.1177/10732748241251583}}, volume = {{31}}, year = {{2024}}, }