Active sensitization to dimethylthiocarbamylbenzothiazol sulphide : An unexpectedly strong rubber contact allergen
(2023) In Contact Dermatitis 88(6). p.472-479- Abstract
Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions... (More)
Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc-Nemar test, two-sided). Conclusions: Results speak for patch test sensitization to DMTBS with cross-reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.
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- author
- Isaksson, Marléne LU ; Bergendorff, Ola LU ; Hamnerius, Nils LU ; Pontén, Ann LU ; Svedman, Cecilia LU ; Hauksson, Inese LU and Bruze, Magnus LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, contact allergy, delayed hypersensitivity, patch testing, rubber chemicals
- in
- Contact Dermatitis
- volume
- 88
- issue
- 6
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85151453422
- pmid:36975130
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.14311
- language
- English
- LU publication?
- yes
- id
- a53ff229-ba9c-45cd-83b8-22337bac727b
- date added to LUP
- 2023-05-23 15:23:24
- date last changed
- 2024-09-21 12:23:57
@article{a53ff229-ba9c-45cd-83b8-22337bac727b, abstract = {{<p>Background: The two dialkylthiocarbamyl benzothiazole sulphides, dimethyl-thiocarbamylbenzothiazole sulphide (DMTBS) and diethylthio-carbamylbenzothiazole sulphide (DETBS) were shown to be good markers of both thiuram and mercaptobenzothiazole sensitivity. Objectives: To investigate if DMTBS and/or DETBS could be better markers of contact allergy to common rubber additives than the ones currently used. Methods: Sixty-eight dermatitis patients were patch tested with DMTBS and DETBS, both at 1% in petrolatum (pet). Because of late reactions in 10 patients, these were retested to DMTBS and DETBS in serial dilutions. Tetramethylthiuram monosulphide (TMTM) 1.0% pet was also tested. Results: At the initial reading Days 3 and 7, no reactions were noted to DMTBS or DETBS. At retesting, 10 of the 68 (15%) patients reacted positively to lower concentrations of DMTBS than the initial test concentration. Seven of 8 also reacted to TMTM. Three of them had positive reactions to DEBTS. All 10 patients had reactions to more diluted solutions to DMBTS than to DEBTS (p = 0.0077; Mc-Nemar test, two-sided). Conclusions: Results speak for patch test sensitization to DMTBS with cross-reactivity to TMTM and also DEBTS. DMTBS and DEBTS could be new markers of rubber allergy but a safe test concentration must be found.</p>}}, author = {{Isaksson, Marléne and Bergendorff, Ola and Hamnerius, Nils and Pontén, Ann and Svedman, Cecilia and Hauksson, Inese and Bruze, Magnus}}, issn = {{0105-1873}}, keywords = {{allergic contact dermatitis; contact allergy; delayed hypersensitivity; patch testing; rubber chemicals}}, language = {{eng}}, number = {{6}}, pages = {{472--479}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Active sensitization to dimethylthiocarbamylbenzothiazol sulphide : An unexpectedly strong rubber contact allergen}}, url = {{http://dx.doi.org/10.1111/cod.14311}}, doi = {{10.1111/cod.14311}}, volume = {{88}}, year = {{2023}}, }