Conjugated linoleic acid increased C-reactive protein in human subjects
(2005) In British Journal of Nutrition 94(5). p.791-795- Abstract
- We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the... (More)
- We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/214010
- author
- Smedman, A ; Basu, S ; Jovinge, Stefan LU ; Nordin Fredrikson, Gunilla LU and Vessby, B
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tumour necrosis, conjugated linoleic acid, C-reactive protein, inflammation, factor-alpha
- in
- British Journal of Nutrition
- volume
- 94
- issue
- 5
- pages
- 791 - 795
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000233096600024
- pmid:16277783
- scopus:27144541775
- ISSN
- 1475-2662
- DOI
- 10.1079/BJN20041419
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012), Experimental Cardiovascular Research Unit (013242110)
- id
- a5dc0684-b49a-4d9e-8b59-38be070a3b2c (old id 214010)
- date added to LUP
- 2016-04-01 11:48:44
- date last changed
- 2022-07-29 18:18:30
@article{a5dc0684-b49a-4d9e-8b59-38be070a3b2c, abstract = {{We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F-2 alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.}}, author = {{Smedman, A and Basu, S and Jovinge, Stefan and Nordin Fredrikson, Gunilla and Vessby, B}}, issn = {{1475-2662}}, keywords = {{tumour necrosis; conjugated linoleic acid; C-reactive protein; inflammation; factor-alpha}}, language = {{eng}}, number = {{5}}, pages = {{791--795}}, publisher = {{Cambridge University Press}}, series = {{British Journal of Nutrition}}, title = {{Conjugated linoleic acid increased C-reactive protein in human subjects}}, url = {{http://dx.doi.org/10.1079/BJN20041419}}, doi = {{10.1079/BJN20041419}}, volume = {{94}}, year = {{2005}}, }