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Aquaporins in pancreatic ductal adenocarcinoma

Bruun-Sørensen, Anne Sofie ; Edamana, Sarannya ; Login, Frédéric H. ; Borgquist, Signe LU and Nejsum, Lene N. (2021) In APMIS 129(12). p.700-705
Abstract

Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progression including epithelial-mesenchymal transition, cellular migration, cell proliferation, invasion, and cellular adhesions. In pancreatic ductal adenocarcinoma, aquaporin-1, aquaporin-3, and aquaporin-5 are overexpressed and have been associated with metastatic processes and poor survival. Thus, aquaporin expression has been suggested as... (More)

Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progression including epithelial-mesenchymal transition, cellular migration, cell proliferation, invasion, and cellular adhesions. In pancreatic ductal adenocarcinoma, aquaporin-1, aquaporin-3, and aquaporin-5 are overexpressed and have been associated with metastatic processes and poor survival. Thus, aquaporin expression has been suggested as diagnostic markers and therapeutic targets in pancreatic ductal adenocarcinoma.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aquaporin, cancer, exocrine pancreas, pancreatic ductal adenocarcinoma, PDAC
in
APMIS
volume
129
issue
12
pages
700 - 705
publisher
Blackwell Munksgaard
external identifiers
  • scopus:85117176114
  • pmid:34582595
ISSN
0903-4641
DOI
10.1111/apm.13184
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 Scandinavian Societies for Medical Microbiology and Pathology
id
a62fb887-66b4-4445-b01d-620b77b997de
date added to LUP
2021-11-16 18:00:12
date last changed
2025-01-13 17:46:23
@article{a62fb887-66b4-4445-b01d-620b77b997de,
  abstract     = {{<p>Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over- or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes involved in cancer development and progression including epithelial-mesenchymal transition, cellular migration, cell proliferation, invasion, and cellular adhesions. In pancreatic ductal adenocarcinoma, aquaporin-1, aquaporin-3, and aquaporin-5 are overexpressed and have been associated with metastatic processes and poor survival. Thus, aquaporin expression has been suggested as diagnostic markers and therapeutic targets in pancreatic ductal adenocarcinoma.</p>}},
  author       = {{Bruun-Sørensen, Anne Sofie and Edamana, Sarannya and Login, Frédéric H. and Borgquist, Signe and Nejsum, Lene N.}},
  issn         = {{0903-4641}},
  keywords     = {{Aquaporin; cancer; exocrine pancreas; pancreatic ductal adenocarcinoma; PDAC}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{700--705}},
  publisher    = {{Blackwell Munksgaard}},
  series       = {{APMIS}},
  title        = {{Aquaporins in pancreatic ductal adenocarcinoma}},
  url          = {{http://dx.doi.org/10.1111/apm.13184}},
  doi          = {{10.1111/apm.13184}},
  volume       = {{129}},
  year         = {{2021}},
}