Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

C-reactive protein as a prognostic factor in intensive care admissions for sepsis : A Swedish multicenter study

Koozi, Hazem LU ; Lengquist, Maria LU orcid and Frigyesi, Attila LU (2020) In Journal of Critical Care 56. p.73-79
Abstract

Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in... (More)

Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P < .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level >100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-reactive protein, Critical care, Intensive care, Mortality, Prediction, Sepsis
in
Journal of Critical Care
volume
56
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:31855709
  • scopus:85076344263
ISSN
0883-9441
DOI
10.1016/j.jcrc.2019.12.009
project
SweCrit, a critical care biobank
language
English
LU publication?
yes
id
a6546f99-b9d9-4507-b3a1-127787c3ae55
date added to LUP
2020-12-18 13:24:54
date last changed
2024-06-14 05:16:18
@article{a6546f99-b9d9-4507-b3a1-127787c3ae55,
  abstract     = {{<p>Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (&lt;100 mg/L) and a high CRP group (&gt;100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P &lt; .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level &gt;100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.</p>}},
  author       = {{Koozi, Hazem and Lengquist, Maria and Frigyesi, Attila}},
  issn         = {{0883-9441}},
  keywords     = {{C-reactive protein; Critical care; Intensive care; Mortality; Prediction; Sepsis}},
  language     = {{eng}},
  pages        = {{73--79}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Critical Care}},
  title        = {{C-reactive protein as a prognostic factor in intensive care admissions for sepsis : A Swedish multicenter study}},
  url          = {{http://dx.doi.org/10.1016/j.jcrc.2019.12.009}},
  doi          = {{10.1016/j.jcrc.2019.12.009}},
  volume       = {{56}},
  year         = {{2020}},
}