C-reactive protein as a prognostic factor in intensive care admissions for sepsis : A Swedish multicenter study
(2020) In Journal of Critical Care 56. p.73-79- Abstract
Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in... (More)
Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P < .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level >100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.
(Less)
- author
- Koozi, Hazem LU ; Lengquist, Maria LU and Frigyesi, Attila LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-reactive protein, Critical care, Intensive care, Mortality, Prediction, Sepsis
- in
- Journal of Critical Care
- volume
- 56
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85076344263
- pmid:31855709
- ISSN
- 0883-9441
- DOI
- 10.1016/j.jcrc.2019.12.009
- project
- SweCrit, a critical care biobank
- language
- English
- LU publication?
- yes
- id
- a6546f99-b9d9-4507-b3a1-127787c3ae55
- date added to LUP
- 2020-12-18 13:24:54
- date last changed
- 2024-07-11 04:06:50
@article{a6546f99-b9d9-4507-b3a1-127787c3ae55, abstract = {{<p>Purpose: C-reactive protein (CRP) is not included in the major intensive care unit (ICU) prognostic tools such as the Simplified Acute Physiology Score (SAPS). We assessed CRP on ICU admission as a SAPS-3 independent risk marker for short-term mortality and length of stay (LOS) in ICU patients with sepsis. Materials and methods: Adult ICU admissions satisfying the Sepsis-3 criteria to four southern Swedish hospitals were retrospectively identified and divided into a low CRP group (<100 mg/L) and a high CRP group (>100 mg/L) based on the admission CRP level. The standardized mortality ratio (SMR) was calculated. Results: A total of 851 admissions were included. The SMR was higher in the high CRP group (0.85 vs. 0.67, P = .001 in the whole sepsis group and 0.85 vs. 0.59, P = .003 in the culture-positive subgroup). The CRP levels also correlated with ICU and hospital LOS in survivors (P < .001 and P = .002), again independent of SAPS-3. Conclusion: An admission CRP level >100 mg/L is associated with an increased risk of ICU and 30-day mortality as well as prolonged LOS in survivors, irrespective of morbidity measured with SAPS-3. Thus, CRP may be a simple, early marker for prognosis in ICU admissions for sepsis.</p>}}, author = {{Koozi, Hazem and Lengquist, Maria and Frigyesi, Attila}}, issn = {{0883-9441}}, keywords = {{C-reactive protein; Critical care; Intensive care; Mortality; Prediction; Sepsis}}, language = {{eng}}, pages = {{73--79}}, publisher = {{Elsevier}}, series = {{Journal of Critical Care}}, title = {{C-reactive protein as a prognostic factor in intensive care admissions for sepsis : A Swedish multicenter study}}, url = {{http://dx.doi.org/10.1016/j.jcrc.2019.12.009}}, doi = {{10.1016/j.jcrc.2019.12.009}}, volume = {{56}}, year = {{2020}}, }