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Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes

Hjort, Rebecka ; Ahlqvist, Emma LU ; Andersson, Tomas ; Alfredsson, Lars ; Carlsson, Per Ola ; Grill, Valdemar ; Groop, Leif LU ; Martinell, Mats ; Sørgjerd, Elin Pettersen and Tuomi, Tiinamaija LU , et al. (2020) In The Journal of clinical endocrinology and metabolism 105(11).
Abstract

PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3... (More)

PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness. RESULTS: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. MAIN CONCLUSIONS: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene-environment interaction, LADA, latent autoimmune diabetes in adults, physical activity, population-based, type 2 diabetes, ANDIS, diabetes
in
The Journal of clinical endocrinology and metabolism
volume
105
issue
11
pages
12 pages
publisher
Oxford University Press
external identifiers
  • scopus:85091808258
  • pmid:32835373
ISSN
1945-7197
DOI
10.1210/clinem/dgaa549
language
English
LU publication?
yes
id
a684a42b-1b1f-4fc6-b888-eab039381876
date added to LUP
2020-10-29 16:12:31
date last changed
2022-08-04 01:28:00
@article{a684a42b-1b1f-4fc6-b888-eab039381876,
  abstract     = {{<p>PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness. RESULTS: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. MAIN CONCLUSIONS: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.</p>}},
  author       = {{Hjort, Rebecka and Ahlqvist, Emma and Andersson, Tomas and Alfredsson, Lars and Carlsson, Per Ola and Grill, Valdemar and Groop, Leif and Martinell, Mats and Sørgjerd, Elin Pettersen and Tuomi, Tiinamaija and Åsvold, Bjørn Olav and Carlsson, Sofia}},
  issn         = {{1945-7197}},
  keywords     = {{gene-environment interaction; LADA; latent autoimmune diabetes in adults; physical activity; population-based; type 2 diabetes; ANDIS; diabetes}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes}},
  url          = {{http://dx.doi.org/10.1210/clinem/dgaa549}},
  doi          = {{10.1210/clinem/dgaa549}},
  volume       = {{105}},
  year         = {{2020}},
}