Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden
Ji, Jianguang LU
; Eng, Charis
and Hemminki, Kari
LU
(2008)
In Journal of Cancer Research and Clinical Oncology
134(5).
p.617-624
- Abstract
Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer... (More)
Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer and liposarcoma was associated with parental bladder cancer and maternal breast cancer. Leiomyosarcoma was associated with maternal breast cancer. The associations of myxosarcoma with melanoma and liposarcoma with non-Hodgkin's lymphoma were noted among siblings. Conclusions: The present study showed that familial clustering of soft tissue tumors was limited to specific subtypes. Because of multiple comparisons, some of observed associations may be negative. Aggregation of melanoma and myxosarcoma among siblings may suggest Werner syndrome. A very small proportion of soft tissue sarcomas may be explained by Li-Fraumeni syndrome. Other novel associations, such as offspring liposarcoma with parental bladder cancer, and liposarcoma and non-Hodgkin's lyhphoma among siblings, may be related to other unidentified familial diseases.
(Less)
- author
- Ji, Jianguang
LU
; Eng, Charis
and Hemminki, Kari
LU
- publishing date
- 2008-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Familial risk, Fibrosarcoma, Leiomyosarcoma, Rhabdomyosarcoma, Soft tissue tumors
- in
- Journal of Cancer Research and Clinical Oncology
- volume
- 134
- issue
- 5
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- pmid:17929055
- scopus:41049084812
- ISSN
- 0171-5216
- DOI
- 10.1007/s00432-007-0327-5
- language
- English
- LU publication?
- no
- id
- a69b9fcd-e47c-4d11-a1b5-fa02e16362a7
- date added to LUP
- 2019-01-30 10:18:10
- date last changed
- 2024-09-17 12:43:38
@article{a69b9fcd-e47c-4d11-a1b5-fa02e16362a7,
abstract = {{<p>Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer and liposarcoma was associated with parental bladder cancer and maternal breast cancer. Leiomyosarcoma was associated with maternal breast cancer. The associations of myxosarcoma with melanoma and liposarcoma with non-Hodgkin's lymphoma were noted among siblings. Conclusions: The present study showed that familial clustering of soft tissue tumors was limited to specific subtypes. Because of multiple comparisons, some of observed associations may be negative. Aggregation of melanoma and myxosarcoma among siblings may suggest Werner syndrome. A very small proportion of soft tissue sarcomas may be explained by Li-Fraumeni syndrome. Other novel associations, such as offspring liposarcoma with parental bladder cancer, and liposarcoma and non-Hodgkin's lyhphoma among siblings, may be related to other unidentified familial diseases.</p>}},
author = {{Ji, Jianguang and Eng, Charis and Hemminki, Kari}},
issn = {{0171-5216}},
keywords = {{Familial risk; Fibrosarcoma; Leiomyosarcoma; Rhabdomyosarcoma; Soft tissue tumors}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{617--624}},
publisher = {{Springer}},
series = {{Journal of Cancer Research and Clinical Oncology}},
title = {{Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden}},
url = {{http://dx.doi.org/10.1007/s00432-007-0327-5}},
doi = {{10.1007/s00432-007-0327-5}},
volume = {{134}},
year = {{2008}},
}