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Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden

Ji, Jianguang LU orcid ; Eng, Charis and Hemminki, Kari LU (2008) In Journal of Cancer Research and Clinical Oncology 134(5). p.617-624
Abstract

Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer... (More)

Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer and liposarcoma was associated with parental bladder cancer and maternal breast cancer. Leiomyosarcoma was associated with maternal breast cancer. The associations of myxosarcoma with melanoma and liposarcoma with non-Hodgkin's lymphoma were noted among siblings. Conclusions: The present study showed that familial clustering of soft tissue tumors was limited to specific subtypes. Because of multiple comparisons, some of observed associations may be negative. Aggregation of melanoma and myxosarcoma among siblings may suggest Werner syndrome. A very small proportion of soft tissue sarcomas may be explained by Li-Fraumeni syndrome. Other novel associations, such as offspring liposarcoma with parental bladder cancer, and liposarcoma and non-Hodgkin's lyhphoma among siblings, may be related to other unidentified familial diseases.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial risk, Fibrosarcoma, Leiomyosarcoma, Rhabdomyosarcoma, Soft tissue tumors
in
Journal of Cancer Research and Clinical Oncology
volume
134
issue
5
pages
8 pages
publisher
Springer
external identifiers
  • pmid:17929055
  • scopus:41049084812
ISSN
0171-5216
DOI
10.1007/s00432-007-0327-5
language
English
LU publication?
no
id
a69b9fcd-e47c-4d11-a1b5-fa02e16362a7
date added to LUP
2019-01-30 10:18:10
date last changed
2024-09-17 12:43:38
@article{a69b9fcd-e47c-4d11-a1b5-fa02e16362a7,
  abstract     = {{<p>Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent pairs with concordant soft tissue tumuors, the SIR was increased but not significant. Offspring soft tissue tumors were associated with paternal prostate and endocrine gland tumors and Hodgkin's disease. Offspring myxosarcoma was associated with paternal endocrine gland tumors. Offspring fibrosarcoma was associated with parental stomach cancer and liposarcoma was associated with parental bladder cancer and maternal breast cancer. Leiomyosarcoma was associated with maternal breast cancer. The associations of myxosarcoma with melanoma and liposarcoma with non-Hodgkin's lymphoma were noted among siblings. Conclusions: The present study showed that familial clustering of soft tissue tumors was limited to specific subtypes. Because of multiple comparisons, some of observed associations may be negative. Aggregation of melanoma and myxosarcoma among siblings may suggest Werner syndrome. A very small proportion of soft tissue sarcomas may be explained by Li-Fraumeni syndrome. Other novel associations, such as offspring liposarcoma with parental bladder cancer, and liposarcoma and non-Hodgkin's lyhphoma among siblings, may be related to other unidentified familial diseases.</p>}},
  author       = {{Ji, Jianguang and Eng, Charis and Hemminki, Kari}},
  issn         = {{0171-5216}},
  keywords     = {{Familial risk; Fibrosarcoma; Leiomyosarcoma; Rhabdomyosarcoma; Soft tissue tumors}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{5}},
  pages        = {{617--624}},
  publisher    = {{Springer}},
  series       = {{Journal of Cancer Research and Clinical Oncology}},
  title        = {{Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden}},
  url          = {{http://dx.doi.org/10.1007/s00432-007-0327-5}},
  doi          = {{10.1007/s00432-007-0327-5}},
  volume       = {{134}},
  year         = {{2008}},
}